Reduced expression of p21-activated protein kinase 1 correlates with poor histological differentiation in pancreatic cancer.
Reduced expression of p21-activated protein kinase 1 correlates with poor histological differentiation in pancreatic cancer.
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p21 激活蛋白激酶 1 表达减少与胰腺癌组织学分化不良相关
DOI：
10.1186/1471-2407-14-650
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发表时间：
2014-09-03
期刊：
影响因子：
3.8
通讯作者：
Xu RH
中科院分区：
文献类型：
--
作者：
Han J;Wang F;Yuan SQ;Guo Y;Zeng ZL;Li LR;Yang J;Wang DS;Liu MY;Zhao H;Liu KY;Liao JW;Zou QF;Xu RH
背景P21活化蛋白激酶1（PAK 1）是Rho GTPases的主要下游效应子，在许多恶性肿瘤中过度表达。PAK 1过表达与某些肿瘤类型的预后不良相关，包括乳腺癌、胃癌和结直肠癌。然而，PAK 1在人胰腺癌中的表达和临床相关性仍然未知。MethodsThe本研究探讨了PAK 1在胰腺癌中表达的临床和预后意义。采用免疫组化方法检测72例原发性胰腺癌和20例肝转移癌组织中PAK 1的表达并进行评分。结果92例胰腺癌原发灶中PAK 1高表达率（38/72，52.8%）明显高于肝转移灶（5/20，25.0%）（P= 0.028）;在72例原发性胰腺癌患者中，PAK 1高表达与年轻（P= 0.038）和中分化或高分化肿瘤（P= 0.007）相关。PAK 1高表达与总生存期（OS）呈正相关（P< 0.005）。PAK 1高表达患者的OS优于PAK 1低表达患者。单变量和多变量分析考克斯回归包括PAK 1和其他预后病理标志物表明高PAK 1免疫染色作为胰腺癌患者生存的预后因素（P< 0.005）。PAK 1表达降低与胰腺癌组织分化差相关。
BackgroundP21-activated protein kinase 1 (PAK1), a main downstream effector of small Rho GTPases, is overexpressed in many malignancies. PAK1 overexpression is associated with poor prognosis in some tumor types, including breast cancer, gastric cancer, and colorectal cancer. However, the expression and clinical relevance of PAK1 expression in human pancreatic cancer remains unknown.MethodsThe present study investigated the clinical and prognostic significance of PAK1 expression in pancreatic carcinoma. We examined and scored the expression of PAK1 by immunohistochemistry in 72 primary pancreatic carcinoma samples and 20 liver metastatic samples. The relationships between PAK1 and clinicopathological parameters and prognosis in primary and metastatic pancreatic cancer were analyzed.ResultsAmong the total 92 cases, primary pancreatic cancer samples had a significantly higher rate (38/72, 52.8%) of high PAK1 expression than liver metastatic samples (5/20, 25.0%) (P= 0.028). Among the 72 primary pancreatic cancer patients, high PAK1 expression was associated with younger age (P= 0.038) and moderately or well differentiated tumor (P= 0.007). Moreover, a positive relationship was found between high PAK1 expression and overall survival (OS) (P< 0.005). Patients with high PAK1 expression had a better OS than those with low PAK1 expression. Univariate and multivariate analysis by Cox regression including PAK1 and other prognostic pathological markers demonstrated high PAK1 immunostaining as a prognostic factor for survival in pancreatic cancer patients (P< 0.005).ConclusionsWe report for the first time that PAK1 is a novel prognostic marker for pathologically confirmed human pancreatic cancer. Reduced expression of PAK1 correlates with poor histological differentiation in pancreatic cancer.
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影响因子：
5.7
作者：
Eswaran, Jeyanthy;Lee, Wen Hwa;Debreczeni, Judit E.;Filippakopoulos, Panagis;Turnbull, Andrew;Fedorov, Oleg;Deacon, Sean W.;Peterson, Jeffrey R.;Knapp, Stefan
通讯作者：
Knapp, Stefan
p21激活激酶1的下调抑制与细胞周期蛋白B1有关的胃癌细胞的生长
影响因子：
6.4
作者：
Liu, Funan;Li, Xiaodong;Li, Feng
通讯作者：
Li, Feng
影响因子：
64.8
作者：
MANSER, E;LEUNG, T;LIM, L
通讯作者：
LIM, L
影响因子：
6.4
作者：
Siu, Michelle K. Y.;Wong, Esther S. Y.;Cheung, Annie N. Y.
通讯作者：
Cheung, Annie N. Y.
影响因子：
5.2
作者：
Li, Liang-Hui;Zheng, Min-Hua;Liu, Bing-Ya
通讯作者：
Liu, Bing-Ya