Immunomodulatory effect of curcumin on hepatic cirrhosis in experimental rats
Immunomodulatory effect of curcumin on hepatic cirrhosis in experimental rats
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DOI：
10.1111/jfbc.13219
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发表时间：
2020-03-25
影响因子：
4
通讯作者：
Ismail, Ahmed H.
中科院分区：
文献类型：
--
作者：
Abo-Zaid, Mabrouk A.;Shaheen, Emad S.;Ismail, Ahmed H.
肝硬化是一种慢性肝病。本研究旨在探讨姜黄素对四氯化碳（CCl 4）诱导的肝硬化大鼠免疫调节作用。通过反复注射CCl_4超过5周，在实验动物中诱导慢性肝纤维化。实验分为5组：第1组注射生理盐水，第2组注射CCl 4，第3、4、5组腹腔注射CCl 4，剂量为3 ml/kg，每周2次，共6周，同时给予浓度为250、200、150 mg/kg的姜黄素。分析不同处理的免疫应答。进行白细胞介素10（IL-10）、促炎细胞因子TNF-α、TGF-1 β和肝脏组织病理学检查。结果显示，姜黄素组IL-10水平显著高于CCl 4组，而TNF-α和TGF-1 β水平显著低于CCl 4组。肝组织病理学检查显示姜黄素处理组几乎保留了肝组织的正常结构。总之，姜黄素抑制肝纤维化和肝纤维化的调节免疫系统机制对入侵者的化学toxicity.Practical应用姜黄素是有据可查的其药用特性，通常用作香料。因此，我们的工作证明了其作为免疫调节剂的有效性。实际上，临床研究表明，姜黄素在几乎所有人体的主要器官系统中显示出多样化和强大的药理作用。这些是：抗糖尿病、抗炎、抗癌、抗衰老、抗氧化、抗菌感染、保肝、神经变性和心血管作用。
Cirrhosis is a chronic liver disease. The present work aimed to evaluate the regulatory immune effect of curcumin in hepatic cirrhosis induced by carbon tetrachloride (CCl4) injections in experimental rats' model. Chronic liver fibrosis was induced in experiment animals by recurrent injections of CCl4 for more than 5 weeks. They were divided into five groups: first group was injected with normal saline, second group with CCl4, third, fourth, and fifth groups were injected with CCl4 (intraperitoneal injection) at dose 3 ml/kg, two times weekly for 6 weeks supplemented with the administration of curcumin with concentrations 250, 200, and 150 mg/kg. Immune response was analyzed to different treatments. Interleukin 10 (IL-10), pro-inflammatory cytokines TNF-alpha, TGF-1 beta, and liver histopathological examinations were conducted. The results showed that estimations of IL-10 concentrations were significantly increased in curcumin groups compared with CCl4 group, whereas TNF-alpha and TGF-1 beta levels were significantly decreased comparing with CCl4 group. The histopathological examinations for liver tissues showed that curcumin treated groups have almost retained the normal structure of liver tissues. In conclusion, curcumin inhibited hepatic fibrosis and liver fibrogenesis with regulation of the immune system mechanism against invader chemical toxicity.Practical applications Curcumin is well documented for its medicinal properties, commonly used as a spice. Our work has thus demonstrated its effectiveness as an immunomodulatory agent. Practically, clinical studies have suggested that curcumin displays a diverse and powerful array of pharmacological effects in nearly all of the human body's major organ systems. These are: antidiabetes, anti-inflammatory, anticancer, antiaging, antioxidant, antibacterial infection, hepatoprotective, neurodegenerative, and cardiovascular effects.