Histopathologic Findings in Peripheral Vestibular System From Patients With Systemic Lupus Erythematosus: A Human Temporal Bone Study
Histopathologic Findings in Peripheral Vestibular System From Patients With Systemic Lupus Erythematosus: A Human Temporal Bone Study
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DOI：
10.1097/mao.0000000000000897
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发表时间：
2015-12-01
影响因子：
2.1
通讯作者：
Cureoglu, Sebahattin
中科院分区：
文献类型：
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作者：
Kariya, Shin;Hizli, Omer;Cureoglu, Sebahattin
假设：我们假设系统性红斑狼疮（SLE）患者颞骨前庭毛细胞存在一种病理状态。背景：感音神经性听力损失与自身免疫性疾病之间存在显著相关性。SLE患者也经常有前庭症状，其病理生理机制尚不清楚。方法：我们检查了8例SLE患者的15例颞骨标本，沿着与17例年龄匹配的健康对照组的21例标本。将样品在水平面上连续切片，并用苏木精和伊红染色。用微分干涉显微镜计数囊状斑、椭圆囊斑和三个半规管嵴中的I型和II型毛细胞数，然后计算毛细胞密度（细胞/0.01 mm（2））。SLE组的囊状斑、椭圆囊斑和上级I型毛细胞的平均密度显著低于对照组，外侧和后半规管。但在所有五个前庭感觉上皮中，II型毛细胞的平均密度在我们的两组之间没有显著差异。在我们的SLE组，前庭毛细胞的平均密度并没有显着相关性与患者的年龄在死亡或SLE的持续时间。结论：I型毛细胞在外周前庭器官的SLE患者的影响。我们的研究结果可以提供一个病理基础的平衡困难的经验，SLE患者。
Hypothesis: We hypothesized that a pathologic condition exists in vestibular hair cells in human temporal bones from patients with systemic lupus erythematosus (SLE).Background: A significant association between sensorineural hearing loss and autoimmune disease has been reported. Patients with SLE also frequently have vestibular symptoms whose pathophysiologic mechanism is unclear.Methods: We examined 15 temporal bone samples from 8 patients with SLE, along with 21 samples from 17 age-matched healthy control patients. The samples were serially sectioned in the horizontal plane and stained with hematoxylin and eosin. Using differential interference contrast microscopy, we counted the number of type I and type II hair cells in the saccular macula, the utricular macula, and the cristae of the three semicircular canals; then, we calculated the hair cell density (cells per 0.01 mm(2)).Results: The mean density of type I hair cells in our SLE group was significantly lower than in our control group in the saccular macula, in the utricular macula, and in the superior, lateral, and posterior semicircular canals. But in all five vestibular sensory epithelia, the mean density of type II hair cells did not significantly differ between our two groups. In our SLE group, the mean density of vestibular hair cells did not significantly correlate with the patient's age at death or with the duration of SLE.Conclusion: Type I hair cells in peripheral vestibular organs are affected in patients with SLE. Our findings could provide a pathologic basis for the difficulty with balance experienced by patients with SLE.