Mechanisms of dealing with DNA damage in terminally differentiated cells
Mechanisms of dealing with DNA damage in terminally differentiated cells
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DOI：
10.1016/j.mrfmmm.2009.11.003
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发表时间：
2010-03-01
影响因子：
2.3
通讯作者：
Dogliotti, E.
中科院分区：
文献类型：
--
作者：
Fortini, P.;Dogliotti, E.
为了保护基因组的完整性，连续暴露于DNA损伤损伤的活细胞配备有称为DNA损伤反应的有效防御机制。其功能是通过DNA修复消除DNA损伤，并通过凋亡清除受损细胞。DNA损伤反应主要在增殖细胞中进行研究，其中细胞周期机制与DNA损伤信号转导整合。目前的知识的机制，DNA修复，DNA损伤信号和细胞死亡的有丝分裂后的细胞经历了不可逆的细胞周期撤回将进行审查。将提供证据表明，在终末分化细胞中的基因组完整性的保护是通过不同的策略比在增殖细胞中实现的。(C)2009爱思唯尔有限公司版权所有。
To protect genomic integrity living cells that are continuously exposed to DNA-damaging insults are equipped with an efficient defence mechanism termed the DNA damage response. Its function is to eliminate DNA damage through DNA repair and to remove damaged cells by apoptosis. The DNA damage response has been investigated mainly in proliferating cells, in which the cell cycle machinery is integrated with the DNA damage signalling. The current knowledge of the mechanisms of DNA repair, DNA damage signalling and cell death of post-mitotic cells that have undergone irreversible cell cycle withdrawal will be reviewed. Evidence will be provided that the protection of the genome integrity in terminally differentiated cells is achieved by different strategies than in proliferating cells. (C) 2009 Elsevier B.V. All rights reserved.