Specific expression of interleukin-1β in temporomandibular joints with internal derangement -: Correlation with clinical findings
Specific expression of interleukin-1β in temporomandibular joints with internal derangement -: Correlation with clinical findings
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DOI：
10.1016/s1079-2104(99)70054-5
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发表时间：
1999-10-01
影响因子：
--
通讯作者：
Nojima, T
中科院分区：
文献类型：
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作者：
Suzuki, T;Segami, N;Nojima, T
客观的。 Interleukin-1 beta 似乎在关节疾病的病理生理学中发挥着重要作用。本研究的目的是分析颞下颌关节内部紊乱中白细胞介素1β的表达。研究设计。使用具有特异性抗体的免疫组织化学技术，我们检查了来自颞下颌关节内部紊乱患者的 20 个人类颞下颌关节样本：5 个摘除的椎间盘和来自颞下颌关节上室滑膜区域的 15 个活检样本。我们还检查了 2 个对照样本。与临床结果相比，IL-1β表达的评估。结果。 Interleukin-1 beta 主要位于滑膜衬里细胞和血管内皮细胞中。 IL-1β 表达与一些临床表现之间存在统计学上显着的相关性。结论。结果表明，白介素-1β可能参与颞下颌关节内部紊乱的发病机制，并且白介素-1β表达的强度可能与临床表现尤其是疼痛相关。
Objective. Interleukin-1 beta appears to play an important role in the pathophysiology of joint diseases. The aim of this study was to analyze the expression of interleukin-1 beta in temporomandibular joint internal derangement.Study design. Using an immunohistochemical technique with specific antibodies, we examined 20 human temporomandibular joint samples from patients with internal derangement of the temporomandibular joint: 5 extirpated disks and 15 biopsy specimens from the synovitic area of the temporomandibular joint upper compartment. We also examined 2 control specimens. The evaluation of interleukin-1 beta expression compared with clinical findings.Results. Interleukin-1 beta was predominantly localized in the synovial lining cells and endothelial cells of blood vessels. Statistically significant correlation was found between interleukin-1 beta expression and some clinical findings.Conclusions. The results suggest that interleukin-1 beta may be involved in the pathogenesis of temporomandibuIar joint internal derangement and that the intensity of interleukin-1 beta expression may correlate with clinical findings, especially pain.