Accelerated loss of skeletal muscle strength in older adults with type 2 diabetes - The Health, Aging, and Body Composition Study
Accelerated loss of skeletal muscle strength in older adults with type 2 diabetes - The Health, Aging, and Body Composition Study
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DOI：
10.2337/dc06-2537
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发表时间：
2007-06-01
期刊：
影响因子：
16.2
通讯作者：
Newman, Anne B.
中科院分区：
文献类型：
--
作者：
Park, Seok Won;Goodpaster, Bret H.;Newman, Anne B.
目的：横断面研究表明，长期患有1型或2型糖尿病的成年人骨骼肌力量低于非糖尿病成年人。该研究的目的是调查有和没有2型糖尿病的社区老年人肌肉质量和力量的纵向变化。研究设计和方法：在健康、衰老和身体组成研究中，我们在基线和3年后对1840名70-79岁的老年人进行了腿部和手臂肌肉质量和力量的检查。用双能x线吸收仪测量局部肌肉质量，用等速和等距测力仪测量肌肉力量。结果-与没有糖尿病的老年人相比，患有2型糖尿病的老年人（n = 305）在腿部肌肉质量（-0.29 +/- 0.03 vs -0,23 +/- 0.01 kg, P < 0.05）和力量（-16.5 +/- 1.2 vs - 12.4 +/- 0.5 Nm, P = 0.001）方面表现出更大的下降。腿部肌肉质量，以每单位肌肉质量（牛顿米每公斤）的最大力量表示，在老年糖尿病患者中也下降得更快（-1.6 +/- 0.2 vs -1.2 +/- 0.1 Nm/kg, P < 0.05）。手臂肌肉力量和质量的变化在糖尿病患者和非糖尿病患者之间没有差异。腿部肌肉力量和质量的快速下降有所减弱，但在控制了人口统计学、身体组成、体育活动、合并慢性疾病、白细胞介素-6和肿瘤坏死因子- α后，仍然很明显。结论：在老年人中，2型糖尿病与腿部肌肉力量和质量的加速丧失有关。
Objective - It has been shown that adults with either long-standing type I or type 2 diabetes had lower skeletal muscle strength than nondiabetic adults in cross-sectional studies, The aim of the study was to investigate longitudinal changes of muscle mass and strength in community-dwelling older adults with and without type 2 diabetes.Research Design and Methods - We examined leg and arm muscle mass and strength at baseline and 3 years later in 1,840 older adults aged 70-79 years in the Health, Aging, and Body Composition Study. Regional muscle mass was measured by dual energy X-ray absorptiometry, and muscle strength was measured using isokinetic and isometric dynamometers.Results - Older adults with type 2 diabetes (n = 305) showed greater declines in the leg muscle mass (-0.29 +/- 0.03 vs. -0,23 +/- 0.01 kg, P < 0.05) and strength (-16.5 +/- 1.2 vs. - 12.4 +/- 0.5 Nm, P = 0.001) compared with older adults without diabetes. Leg muscle quality, expressed as maximal strength per unit of muscle mass (Newton meters per kilogram), also declined more rapidly in older adults with diabetes (-1.6 +/- 0.2 vs. -1.2 +/- 0.1 Nm/kg, P < 0.05). Changes in arm muscle strength and quality were not different between those with and without diabetes. Rapid declines in leg muscle strength and quality were attenuated but remained significant after controlling for demographics, body composition, physical activity, combined chronic diseases, interleukin-6, and tumor necrosis factor-alpha.Conclusions - In older adults, type 2 diabetes is associated with accelerated loss of leg muscle strength and quality.