Sympathetic control of adrenal secretion of enkephalins after hemorrhage in awake dogs.
Sympathetic control of adrenal secretion of enkephalins after hemorrhage in awake dogs.
复制标题
清醒狗出血后交感神经控制肾上腺脑啡肽分泌。
DOI：
10.1152/ajpregu.1986.251.2.r341
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发表时间：
1986
期刊：
影响因子：
--
通讯作者：
Gann,DS
中科院分区：
文献类型：
--
作者：
Engeland,WC;Bereiter,DF;Gann,DS
Adrenomedullary secretion of methionine (Met)-enkephalin and of leucine (Leu)-enkephalin was measured in awake trained dogs subjected to 10 or 20% hemorrhage. Enkephalin secretory rates increased in proportion to the magnitude of hemorrhage with the ratio of Met-enkephalin to Leu-enkephalin being approximately 4:1. Arterial concentrations of enkephalins reflected adrenal secretion only in dogs exhibiting the largest secretory responses to hemorrhage. Cross-correlation analysis of 12 individual experiments showed that Met-enkephalin and epinephrine secretory rates were maximally correlated at 0-min delay, suggesting that enkephalins are cosecreted with catecholamines. The molar ratio in adrenal venous blood of epinephrine to Met-enkephalin ranges from 480 +/- 50 to 570 +/- 60. Chronic denervation of the adrenal by removing thoracic and lumbar splanchnic nerves prevented the Met-enkephalin and catecholamine secretory responses to hemorrhage. These data show that the adrenal medulla secretes enkephalins in response to stimuli activated by hemorrhage. These findings suggest that secretion of opiate-like peptides into the peripheral circulation may be a component of the sympathetic response to trauma.
