Malaria attributable to the HIV-1 epidemic, sub-Saharan Africa
Malaria attributable to the HIV-1 epidemic, sub-Saharan Africa
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DOI：
10.3201/eid1109.050337
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发表时间：
2005-09-01
影响因子：
11.8
通讯作者：
Nahlen, BL
中科院分区：
文献类型：
--
作者：
Korenromp, EL;Williams, BG;Nahlen, BL
我们评估了艾滋病毒-1对撒哈拉以南非洲人口疟疾的影响。根据文献审查得出的艾滋病毒感染者疟疾相对风险适用于每个国家的艾滋病毒感染者，按年龄组、CD 4细胞计数层以及城市与农村居住地分列。HIV感染者中CD 4计数的分布模型假设血清转换后CD 4呈线性下降。从41个国家的平均情况来看，HIV-1的影响有限（尽管数量不确定），因为这两种疾病的地理分布不同，年龄模式也截然不同。然而，在博茨瓦纳、津巴布韦、斯威士兰、南非和纳米比亚，临床疟疾发病率增加了2.5%，
We assessed the impact of HIV-1 on malaria in the sub-Saharan African population. Relative risks for malaria in HIV-infected persons, derived from literature review, were applied to the HIV-infected population in each country, by age group, stratum of CD4 cell count, and urban versus rural residence. Distributions of CD4 counts among HIV-infected persons were modeled assuming a linear decline in CD4 after seroconversion. Averaged across 41 countries, the impact of HIV-1 was limited (although quan- titatively uncertain) because of the different geographic distributions and contrasting age patterns of the 2 diseases. However, in Botswana, Zimbabwe, Swaziland, South Africa, and Namibia, the incidence of clinical malaria increased by