The Lateral and Ventromedial Prefrontal Cortex Work as a Dynamic Integrated System: Evidence from fMRI Connectivity Analysis
The Lateral and Ventromedial Prefrontal Cortex Work as a Dynamic Integrated System: Evidence from fMRI Connectivity Analysis
复制标题
DOI：
10.1162/jocn.2009.21012
复制
发表时间：
2009-01-01
影响因子：
3.2
通讯作者：
Rippon, Gina
中科院分区：
文献类型：
--
作者：
Longe, Olivia;Senior, Carl;Rippon, Gina
最近的功能磁共振成像（fMRI）研究认知和奖励加工之间的相互作用发现，外侧前额叶皮层（PFC）区优先激活的认知需求和奖励水平的增加。相反，腹内侧前额叶皮层（VMPFC）区域在相同条件下的激活减少，表明认知和情绪处理区域之间可能存在相互关系。我们报告了一个奖励性工作记忆任务的fMRI研究，我们进一步探讨了奖励和认知加工之间的关系是如何介导的。我们不仅评估在不同的实验环境中的外侧PFC和VMPFC脑区之间的相互神经连接的完整性，但也测试是否额外的皮质和皮质下区域影响这种关系。心理生理学的相互作用分析被用来作为功能连接的措施，以表征认知和动机变量之间的横向PFC和VMPFC的连接的影响。心理生理学的相互作用揭示了负面的功能连接之间的横向PFC和VMPFC的背景下，高记忆负荷，高记忆负荷与高度激励的背景下，但不是在单独的奖励的背景下。生理生理学的相互作用进一步表明，背前扣带回和尾状核调节这一途径。这些研究结果提供了证据，外侧PFC和VMPFC区域之间的动态相互作用，并与VMPFC在认知要求高的任务中的情绪门控作用是一致的。我们的研究结果也支持情绪障碍的神经心理学理论，这些理论长期以来一直强调抑郁症中情绪/动机和认知过程之间的功能失调关系。
Recent functional magnetic resonance imaging (fMRI) investigations of the interaction between cognition and reward processing have found that the lateral prefrontal cortex (PFC) areas are preferentially activated to both increasing cognitive demand and reward level. Conversely, ventromedial PFC (VMPFC) areas show decreased activation to the same conditions, indicating a possible reciprocal relationship between cognitive and emotional processing regions. We report an fMRI study of a rewarded working memory task, in which we further explore how the relationship between reward and cognitive processing is mediated. We not only assess the integrity of reciprocal neural connections between the lateral PFC and VMPFC brain regions in different experimental contexts but also test whether additional cortical and subcortical regions influence this relationship. Psychophysiological interaction analyses were used as a measure of functional connectivity in order to characterize the influence of both cognitive and motivational variables on connectivity between the lateral PFC and the VMPFC. Psychophysiological interactions revealed negative functional connectivity between the lateral PFC and the VMPFC in the context of high memory load, and high memory load in tandem with a highly motivating context, but not in the context of reward alone. Physiophysiological interactions further indicated that the dorsal anterior cingulate and the caudate nucleus modulate this pathway. These findings provide evidence for a dynamic interplay between lateral PFC and VMPFC regions and are consistent with an emotional gating role for the VMPFC during cognitively demanding tasks. Our findings also support neuropsychological theories of mood disorders, which have long emphasized a dysfunctional relationship between emotion/motivational and cognitive processes in depression.