Effect of milk fermented with Lactobacillus acidophilus strain L-92 on symptoms of Japanese cedar pollen allergy:: A randomized placebo-controlled trial
Effect of milk fermented with Lactobacillus acidophilus strain L-92 on symptoms of Japanese cedar pollen allergy:: A randomized placebo-controlled trial
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DOI：
10.1271/bbb.69.1652
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发表时间：
2005-09-01
影响因子：
1.6
通讯作者：
Fujiwara, S
中科院分区：
文献类型：
--
作者：
Ishida, Y;Nakamura, F;Fujiwara, S
进行了一项安慰剂对照、单盲研究，以评估嗜酸乳杆菌菌株L-92（L-92）对日本雪松花粉过敏症状的影响。本研究是在2002年和2003年的季节日本雪松授粉。23名内部志愿者被要求饮用100 ml用L-92发酵的热处理牛奶，其中含有5 × 10（10）的细菌，每天两次，连续6周。在2003年的季节进行了为期10周的类似研究，但细菌的每日剂量为2 × 10（10）。在2002年观察到眼部疼痛-药物评分（SMS）的显著改善，在2003年观察到生活窘迫评分的显著改善。这些数据表明，每日口服不少于2 x 10（10）个热处理L-92细胞可改善日本雪松花粉症的症状，从而有助于减少伴随药物的剂量。然而，在这些试验中，血液参数未受到显著影响。
A placebo-controlled, single-blind study was conducted to evaluate the effects of Lactobacillus acidophilus strain L-92 (L-92 on the symptoms of Japanese cedar-pollen allergy. This study was carried out during the 2002 and 2003 seasons of Japanese cedar pollination. Twenty-three in-house volunteers were asked to drink 100 ml of heat-treated milk fermented with L-92 containing 5 x 10(10) of the bacteria, twice a day, for 6 consecutive weeks. A similar study was carried out during the 2003 season for 10 weeks, but the daily dose of bacteria was 2 x 10(10). A significant improvement of the ocular symptom-medication score (SMS) was observed in 2002 and of the score of distress of life in 2003. These data show that a daily oral intake of not less than 2 x 10(10) heat-treated L-92 cells improved the symptoms of Japanese cedar pollinosis, thereby contributing to reduce the dose of concomitant medications. However, no blood parameter was significantly affected in these trials.