The Same Chromosome 9p21.3 Locus Is Associated With Type 2 Diabetes and Coronary Artery Disease in a Chinese Han Population
The Same Chromosome 9p21.3 Locus Is Associated With Type 2 Diabetes and Coronary Artery Disease in a Chinese Han Population
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同一染色体 9p21.3 位点与中国汉族人群中的 2 型糖尿病和冠状动脉疾病相关
DOI：
10.2337/db10-0185
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发表时间：
2011-02-01
期刊：
影响因子：
7.7
通讯作者：
Wang, Qing K.
中科院分区：
文献类型：
--
作者：
Cheng, Xiang;Shi, Lisong;Wang, Qing K.
目的近年来的全基因组关联研究（GWAS）显示，9p21.3位点与2型糖尿病相关。在这项研究中，我们在GeneID中国汉族人群中进行了一项大规模病例对照研究，以1）进一步复制9p21.3 2型糖尿病GWAS单核苷酸多态性（SNP）的相关性，2）评估这些SNP与冠状动脉疾病的相关性。研究设计和方法在两个GeneID队列的3，167名中国汉族个体中对三种SNP（rs 2383208、rs 10811661和rs 10757283）进行基因分型。采用病例-对照关联设计确定SNPs与2型糖尿病和冠状动脉疾病的关联。计算冠状动脉疾病受试者的Gensini评分，并检测其与变异的相关性。多变量logistic回归进行关联研究。结果：在GeneID人群中，三个SNPs中的两个与2型糖尿病之间的关联被复制（rs 2383208，P = 0.936; rs 10811661-T，P = 0.02，比值比[OR] = 1.23; rs 10757283-C，P = 0.003，OR = 1.30）。同样的两个SNPs也有助于冠状动脉疾病（CAD）的风险（rs 10811661-T，P = 0.002，OR = 1.19; rs 10757283-C，P = 0.003，OR = 1.18）。此外，rs 10757283与Gensini评分系统估计的冠状动脉粥样硬化严重程度相关（风险等位基因C，定量-特质回归校正P = 0.002）。结论：据我们所知，我们的研究结果首次表明，在我们的GeneID中国汉族人群中，以SNPs rs 10811661和rs 10757283为代表的相同9p21.3位点与2型糖尿病和冠状动脉疾病的风险有关。
OBJECTIVE Recent genome-wide association studies (GWAS) revealed that a 9p21.3 locus was associated with type 2 diabetes. In this study, we carried out a large-scale case-control study in the GeneID Chinese Han population to 1) further replicate the association of 9p21.3 type 2 diabetes GWAS single nucleotide polymorphisms (SNPs) and 2) assess the association of these SNPs with coronary artery disease. RESEARCH DESIGN AND METHODS Three SNPs (rs2383208, rs10811661, and rs10757283) were genotyped in two GeneID cohorts of 3,167 Chinese Han individuals. Case-control association design was used to determine the association of the SNPs with type 2 diabetes and coronary artery disease. Gensini scores were calculated in the coronary artery disease subjects and were tested for association with the variants. Multivariate logistic regressions were performed on association studies. RESULTS The association between two of the three SNPs and type 2 diabetes was replicated in the GeneID population (rs2383208, P = 0.936; rs10811661-T, P = 0.02, odds ratio [OR] = 1.23; rs10757283-C, P = 0.003, OR = 1.30). The same two SNPs also contributed to the risk of coronary artery disease (CAD) (rs10811661-T, P = 0.002, OR = 1.19; rs10757283-C, P = 0.003, OR = 1.18). In addition, rs10757283 was associated with severity of coronary atherosclerosis estimated by the Gensini scoring system (risk allele C, quantitative-trait regression adjusted P = 0.002). CONCLUSIONS For the first time to our knowledge, our results indicated that the same 9p21.3 locus, represented by SNPs rs10811661 and rs10757283, contributed to the risk of type 2 diabetes and coronary artery disease in our GeneID Chinese Han population.