Whole-body optical Imaging in animal models to assess cancer development and progression
Whole-body optical Imaging in animal models to assess cancer development and progression
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DOI：
10.1158/1078-0432.ccr-07-0402
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发表时间：
2007-06-15
影响因子：
11.5
通讯作者：
Lowik, Clemens W. G. M.
中科院分区：
文献类型：
--
作者：
Kaijzel, Eric L.;van der Pluijm, Gabri;Lowik, Clemens W. G. M.
使用不同的基于光学的成像模型来研究肿瘤进展和转移，特别强调骨和骨髓的转移。我们描述了光学成像如何可以用来跟踪肿瘤发展和治疗反应的重要过程，包括血管生成，细胞凋亡和蛋白水解。最后，我们讨论了翻译的一个光学成像模式，近红外荧光，从动物验证研究中的应用程序在临床相关的癌症管理。
Different optical-based imaging models were used to investigate tumor progression and metastasis with particular emphasis on metastasis to bone and bone marrow. We describe how optical imaging can be used to follow important processes in tumor development and treatment response, including angiogenesis, apoptosis, and proteolysis. Finally, we discuss the translation of one optical imaging modality, near-IR fluorescence, from animal validation studies to applications in the clinic related to cancer management.