Energy addiction and lymphocyte differentiation: a new role for the liver kinase B1 kinase.
Energy addiction and lymphocyte differentiation: a new role for the liver kinase B1 kinase.
复制标题
能量成瘾和淋巴细胞分化：肝激酶 B1 激酶的新作用。
DOI：
10.1002/eji.200940206
复制
发表时间：
2010
影响因子：
5.4
通讯作者：
Sawai,Catherine
中科院分区：
文献类型：
--
作者：
Aifantis,Iannis;Sawai,Catherine
淋巴细胞发育是一个增殖与分化相结合的过程。为了进行有效的增殖，淋巴细胞必须协调进入细胞周期与增加的代谢。信号传导途径，如抗原和细胞因子受体的下游，以及直接控制细胞代谢的特定调节剂，才刚刚开始被定义。本期《欧洲免疫学杂志》的一项研究表明，肝激酶B1（LKB 1）是细胞代谢的调节剂。LKB1缺乏导致T细胞分化受阻，凋亡增加以及成熟T细胞存活受损。这项研究强调了LKB1在T细胞发育和功能中的重要性，但正如本评论中所讨论的，关于LKB1的调节和其他功能仍然存在一些有趣的问题。
Lymphocyte development is a process in which proliferation is coupled to differentiation. In order to undergo efficient proliferation, lymphocytes must coordinate the entry into cell cycle with increased metabolism. The signaling pathways, like those downstream of antigen and cytokine receptors, and specific regulators that directly control cell metabolism are only beginning to be defined. A study in this issue of theEuropean Journal of Immunology, demonstrates that the liver kinase B1 (LKB1) is a regulator of cellular metabolism. Deficiency in LKB1 results in a block in T‐cell differentiation, increased apoptosis, as well as impaired survival of mature T cells. This study highlights the importance of LKB1 in T‐cell development and function, but as discussed in thisCommentary, a number of intriguing questions concerning the regulation and additional functions of LKB1 remain.