The 20-Year Voyage Aboard the Journal of Alzheimer's Disease: Docking at 'Type 3 Diabetes', Environmental/Exposure Factors, Pathogenic Mechanisms, and Potential Treatments.
The 20-Year Voyage Aboard the Journal of Alzheimer's Disease: Docking at 'Type 3 Diabetes', Environmental/Exposure Factors, Pathogenic Mechanisms, and Potential Treatments.
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DOI：
10.3233/jad-170829
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Wands JR
中科院分区：
文献类型：
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作者：
de la Monte SM;Tong M;Wands JR
《阿尔茨海默病杂志》(JAD)创刊于1998年，自阿尔茨海默病(AD)诞生以来，发表了一系列临床、病理学、分子、生化、流行病学、实验和综述文章，在拓宽阿尔茨海默病(AD)的研究领域方面发挥了关键作用。这篇文章讲述了我作为一名作家的旅程，在该杂志存在的20年里，我为JAD撰写了一些文章。回过头来看，似乎值得注意的是，我们团队的大量工作标志着一条从AD发病机制中的血管、压力和线粒体因素研究开始的试验，爆炸式地发展成“3型糖尿病”的概念，并继续描述环境、暴露和生活方式因素如何促进神经退化，以及哪些治疗策略可以逆转神经退化级联反应。
The Journal of Alzheimer’s Disease (JAD), founded in 1998, played a pivotal role in broadening the field of research on Alzheimer’s disease (AD) by publishing a diverse range of clinical, pathological, molecular, biochemical, epidemiological, experimental, and review articles from its birth. This article recounts my own journey as an author who contributed articles to JAD over the 20 years of the journal’s existence. In retrospect, it seems remarkable that a considerable body of work that originated from our group marks a trail that began with studies of vascular, stress, and mitochondrial factors in AD pathogenesis, exploded into the concept of ‘Type 3 Diabetes’, and continued with the characterization of how environmental, exposure, and lifestyle factors promote neurodegeneration and which therapeutic strategies could reverse the neurodegeneration cascade.