Restriction-map variation in the Notch region of Drosophila melanogaster.
Restriction-map variation in the Notch region of Drosophila melanogaster.
复制标题
果蝇Notch 区域的限制性图谱变异。
DOI：
10.1093/oxfordjournals.molbev.a040475
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发表时间：
1988
影响因子：
10.7
通讯作者：
Langley,CH
中科院分区：
文献类型：
--
作者：
Schaeffer,SW;Aquadro,CF;Langley,CH
用四种限制性内切酶对全世界范围内的37条黑腹果蝇X染色体样本的Notch基因座的60 kb区域进行了分析。任意两条随机选择的同源染色体在143个核苷酸中有一个是杂合的（θ = 0.007）。取样的染色体含有不超过一个插入/缺失。在取样的37条染色体中观察到的四个插入和一个缺失位于Notch转录物的3'端;一个插入在样品中出现两次。Notch区域的连锁不平衡量似乎低于D.黑腹菌观察到的连锁不平衡的少数情况可能是由于非洲人口的地理分化。Notch区域的遗传变异估计值与D.黑腹果蝇，这表明X染色体上的分子遗传变异并没有通过对轻微有害等位基因的选择而显著减少。
A worldwide sample of 37 X chromosomes of Drosophila melanogaster was analyzed with four restriction endonucleases for a 60-kb region of the Notch locus. Any two randomly chosen homologous chromosomes were heterozygous at one in 143 nucleotides (theta = 0.007). The chromosomes that were sampled contained no more than one insertion/deletion. The four insertions and one deletion observed in the 37 chromosomes sampled were located 3' to the Notch transcript; one insertion was represented twice in the sample. The amount of linkage disequilibrium in the Notch region appears to be lower than that of the alcohol dehydrogenase locus in D. melanogaster. The few instances of linkage disequilibrium observed could be due to geographic differentiation of African populations. The genetic variation estimates in the Notch region were comparable with those of the alcohol dehydrogenase region in D. melanogaster, suggesting that molecular genetic variation on the X chromosome is not dramatically reduced by selection against slightly deleterious alleles.