Femtosecond laser induced flexibility change of human donor lenses
Femtosecond laser induced flexibility change of human donor lenses
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DOI：
10.1016/j.visres.2009.04.028
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发表时间：
2009-07-01
期刊：
影响因子：
1.8
通讯作者：
Lubatschowski, Holger
中科院分区：
文献类型：
--
作者：
Schumacher, Silvia;Oberheide, Uwe;Lubatschowski, Holger
背景：根据亥姆霍兹调节理论，调节幅度的损失是由晶状体日益硬化引起的，而睫状肌和晶状体囊主要不受年龄的影响。提供动态调节能力的老花眼的永久性治疗方法是最近的研究领域。本文遵循的概念使用飞秒激光脉冲，通过在晶状体组织内创建滑动平面来提高其灵活性，从而潜在地克服晶状体变形能力的损失。方法：该研究的目的是表明，通过将紧密聚焦的近红外飞秒激光脉冲施加到晶状体组织中，可以增加人类供体晶状体的灵活性。从而通过光致破裂效应分离组织。在41个人类捐献晶状体的组织内切出一定图案的滑移面，并使用Fisher旋转试验比较激光治疗前后晶状体的变形能力。结果：激光治疗导致晶状体的变形能力增加。治疗后晶状体ap厚度平均增加97μm±14μm。 Fisher旋转测试表明，在1620rpm的转速下，晶状体的变形能力增加了16%。结论：用飞秒激光在晶状体组织内部创建滑翔面可以改变晶状体的变形能力。这可能预示着未来可能有一种治疗老花眼的方法。 (C) 2009 Elsevier Ltd. 保留所有权利。
Background: According to the Helmholtz theory of accommodation the loss of accommodation amplitude is caused by the growing sclerosis of the crystalline lens, whereas the ciliary muscle and the lens capsule are mainly uneffected by age. A permanent treatment method for presbyopia which offers a dynamic accommodation ability is a recent field of study. The concept followed in this paper uses femtosecond laser pulses to potentially overcome the loss of deformation ability of the crystalline lens by creating gliding planes inside the lens tissue to improve its flexibility.Methods: The aim of the study is to show that the flexibility of human donor lenses can be increased by applying tightly focused near infrared femtosecond laser pulses into the lens tissue. Thereby the tissue is separated by the photodisruption effect. A certain pattern of gliding planes is cut inside the tissue of 41 human donor lenses and the deformation ability of the lenses are compared using the Fisher spinning test before and after laser treatment.Results: The laser treatment results in an increased deformation ability of the crystalline lens. The lens ap thickness increases on average by 97 mu m 14 mu m after the treatment. The Fisher spinning test shows an increase of 16% in deformation ability of the lens at a rotational speed of 1620 rpm.Conclusion: The creation of gliding planes with a fs laser inside the crystalline lens tissue can change the deformation ability of the lens. This might be an indication for a possible method to treat presbyopia in future. (C) 2009 Elsevier Ltd. All rights reserved.