A region of the vertebrate neural plate in which neighbouring cells can adopt neural or epidermal fates
A region of the vertebrate neural plate in which neighbouring cells can adopt neural or epidermal fates
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DOI：
10.1016/s0960-9822(00)00601-1
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发表时间：
2000-07-13
期刊：
影响因子：
9.2
通讯作者：
Storey, KG
中科院分区：
文献类型：
--
作者：
Brown, JM;Storey, KG
果蝇神经发生区的细胞要么成为神经干细胞，要么成为表皮，前者的选择需要原神经基因的激活[1]，相反，通常认为脊椎动物神经板中的所有细胞都为神经管做出贡献，因此不需要选择单个神经前体(例如，[2])。这里我们提供了鸡尾状神经板(CNP)的详细命运图，CNP是产生后脑和脊髓的细胞群体。我们证明，这是神经板的一个独特区域，在这里相邻的细胞可以对神经管或表皮做出贡献，此外，神经管前体以大致的吻尾顺序离开CNP，并在神经管的不同部分产生它们或它们的后代表现为神经干细胞[3]。我们的数据表明，神经细胞和表皮细胞的命运是在CNP内逐个细胞的基础上获得的，因此以与苍蝇惊人地相似的方式获得。事实上，该区域神经细胞命运的分配可能被证明是由苍蝇神经基因的功能同源基因(鸡无毛-毛囊同源基因4 cash4)介导的，该基因在该细胞群体中异质性地表达[4]。
Cells in the neurogenic region of the fly, Drosophila melanogaster, become either neural stem cells or epidermis and the selection of the former requires the activity of the proneural genes [1], In contrast, it is commonly thought that all cells in the vertebrate neural plate contribute to the neural tube and that consequently there is no need for the selection of individual neural precursors (e.g,, [2]), Here we present a detailed fate map of the chick caudal neural plate (CNP), a cell population that generates the posterior hindbrain and spinal cord. We show that this is a unique region of the neural plate where neighbouring cells can contribute to neural tube or epidermis, further, neural tube precursors leave the CNP in an approximate rostro caudal order and give rise to discrete portions of the neural tube where they or their progeny behave as neural stem cells [3]. Our data suggest that neural and epidermal cell fates are acquired on a cell by-cell basis within the CNP and thus in a manner strikingly similar to that in the fly. Indeed, the assignment of neural cell fate in this region may prove to be mediated by the functional homologue of the fly proneural genes (chick achaete-scute homologue 4 cash4), which is expressed heterogeneously within this cell population [4].