A technical report from the Italian SARS-CoV-2 outbreak. Postmortem sampling and autopsy investigation in cases of suspected or probable COVID-19
A technical report from the Italian SARS-CoV-2 outbreak. Postmortem sampling and autopsy investigation in cases of suspected or probable COVID-19
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DOI：
10.1007/s12024-020-00258-9
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发表时间：
2020-05-12
影响因子：
1.8
通讯作者：
Fineschi, Vittorio
中科院分区：
文献类型：
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作者：
Santurro, Alessandro;Scopetti, Matteo;Fineschi, Vittorio
SARS-CoV-2（严重急性呼吸系统综合征冠状病毒2型）是导致COVID-19（2019冠状病毒病）的冠状病毒，该冠状病毒于2019年12月31日左右在中国引发了一系列肺炎病例，随后蔓延至地球仪。目前，COVID-19在全球范围内是一种卫生紧急情况，严重情况下会导致肺炎、严重急性呼吸系统综合征、多器官功能障碍或衰竭以及死亡。在SARS-CoV-2感染的科学知识和证据有限的背景下，对于必须对COVID-19病例进行尸检调查的病理学家来说，指导变得越来越必要。本报告的目的是分享适用于COVID-19相关死亡病例的程序，特别是在没有医疗干预和没有确定的SARS-CoV-2感染和/或COVID-19诊断的情况下死亡的病例，从而为当前COVID-19大流行的诊断活动提供支持。为此，提供了正确拭子采集、尸检研究和组织采样的标准操作规程。
SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) is a coronavirus responsible for COVID-19 (coronavirus disease 2019) which resulted in a cluster of cases of pneumonia that originated in China around 31 December 2019 and has subsequently spread across the globe. Currently, COVID-19 represents a health emergency worldwide, leading, in severe cases, to pneumonia, severe acute respiratory syndrome, multiorgan dysfunction or failure, and death. In the context of limited scientific knowledge and evidence of SARS-CoV-2 infection, guidance is becoming increasingly necessary for pathologists who have to perform postmortem investigations on COVID-19 cases. The aim of the present report is to share a procedure applicable to cases of COVID-19-related death, particularly in cases of death without medical intervention and in the absence of an ascertained SARS-CoV-2 infection and/or COVID-19 diagnosis, therefore providing support for diagnostic activity in the present COVID-19 pandemic. For this purpose, a standard operating procedure for correct swab collection, autopsy investigation and tissue sampling is provided.