EICO (Expression-based Imprint Candidate Organizer): finding disease-related imprinted genes
EICO (Expression-based Imprint Candidate Organizer): finding disease-related imprinted genes
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DOI：
10.1093/nar/gkh093
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发表时间：
2004-01-01
影响因子：
14.9
通讯作者：
Okazaki, Y
中科院分区：
文献类型：
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作者：
Nikaido, I;Saito, C;Okazaki, Y
我们开发了一个专门用于研究印迹疾病基因的综合数据库。该数据库包含由RIKEN全长小鼠cDNA微阵列研究确定的新的候选印迹基因，验证单核苷酸多态性（SNP）的信息，以确认使用相互小鼠杂交印迹和印迹相关疾病位点在小鼠和人类基因组中的预测物理位置。它有两个用户友好的搜索界面：SNP中心视图（麝香：MoUse SNP CATALYST）和候选基因中心视图（CITE：候选印迹转录本表达）。数据库EICO（基于表达的印记候选组织者）可通过万维网（http：//fantom2.gsc.riken.jp/EICODB/）和DAS客户端软件访问。这些数据和界面有助于理解哺乳动物遗传性状中的印记机制。
We have developed an integrated database that is specialized for the study of imprinted disease genes. The database contains novel candidate imprinted genes identified by the RIKEN full-length mouse cDNA microarray study, information on validated single nucleotide polymorphisms (SNPs) to confirm imprinting using reciprocal mouse crosses and the predicted physical position of imprinting-related disease loci in the mouse and human genomes. It has two user-friendly search interfaces: the SNP-central view (MuSCAT: MoUse SNP CATalog) and the candidate gene-central view (CITE: Candidate Imprinted Transcripts by Expression). The database, EICO (Expression-based Imprint Candidate Organizer), can be accessed via the World Wide Web (http://fantom2.gsc.riken.jp/EICODB/) and the DAS client software. These data and interfaces facilitate understanding of the mechanism of imprinting in mammalian inherited traits.