The tree shrews: adjuncts and alternatives to primates as models for biomedical research
The tree shrews: adjuncts and alternatives to primates as models for biomedical research
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DOI：
10.1034/j.1600-0684.2003.00022.x
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发表时间：
2003-06-01
影响因子：
0.7
通讯作者：
Chow, P
中科院分区：
文献类型：
--
作者：
Cao, J;Yang, EB;Chow, P
树鼩是一种非啮齿类的灵长类小动物。利用它们来建立用于医学和生物学研究的动物模型的兴趣越来越大。本文综述了树鼩在病毒性肝炎、肝细胞癌（HCC）、近视和心理社会应激方面的体内研究中的应用。由于树鼩（Tupaia belangeri）及其肝细胞在体内和体外对人B肝炎病毒（HBV）感染的易感性，这些动物已被用于建立人肝炎病毒诱导的肝炎和人HBV和黄曲霉毒素B1相关的HCC模型。由于这些动物在进化上与灵长类动物在遗传学上接近，并且在某些物种中具有发达的视觉系统和色觉，因此它们已被用于建立近视模型。由于从属雄性树鼩的戏剧性行为，生理和神经内分泌变化与抑郁症患者中观察到的相似，树鼩已成功地用于实验研究心理社会压力。然而，树鼩作为研究模型有着重要的前景，这些动物可以在生物医学研究中得到很大的利用。
The tree shrews are non-rodent, primate-like, small animals. There is increasing interest in using them to establish animal models for medical and biological research. This review focuses on the use of the tree shrews in in vivo studies on viral hepatitis, hepatocellular carcinoma (HCC), myopia, and psychosocial stress. Because of the susceptibility of the tree shrews (Tupaia belangeri) and their hepatocytes to infection with human hepatitis B virus (HBV) in vivo and in vitro, these animals have been used to establish human hepatitis virus-induced hepatitis and human HBV- and aflatoxin B1-associated HCC models. As these animals are phylogenetically close to primates in evolution and have a well-developed visual system and color vision in some species, they have been utilized to establish myopia models. Because dramatic behavioral, physiological, and neuroendocrine changes in subordinate male tree shrews are similar to those observed in depressed human patients, the tree shrews have been successfully employed to experimentally study psychosocial stress. However, the tree shrews holds significant promise as research models and great use could be made of these animals in biomedical research.