Targeted cancer therapy
Targeted cancer therapy
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DOI：
10.1038/nature03095
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发表时间：
2004-11-18
期刊：
影响因子：
64.8
通讯作者：
Sawyers, C
中科院分区：
文献类型：
--
作者：
Sawyers, C
细胞周期进程和分裂的正常调节被破坏是导致癌症的事件的核心。复杂的调控因子网络、肿瘤微环境和应激信号（如DNA损伤引起的信号）决定了癌细胞是增殖还是死亡。在理解癌症发展的分子变化方面的最新进展提供了特异性靶向故障分子和途径以实现更有效和合理的癌症治疗的前景。
Disruption of the normal regulation of cell-cycle progression and division lies at the heart of the events leading to cancer. Complex networks of regulatory factors, the tumour microenvironment and stress signals, such as those resulting from damaged DNA, dictate whether cancer cells proliferate or die. Recent progress in understanding the molecular changes that underlie cancer development offer the prospect of specifically targeting malfunctioning molecules and pathways to achieve more effective and rational cancer therapy.