ISOLATION OF NEOCOPIAMYCIN A FROM STREPTOMYCES-HYGROSCOPICUS VAR CRYSTALLOGENES, THE COPIAMYCIN SOURCE
ISOLATION OF NEOCOPIAMYCIN A FROM STREPTOMYCES-HYGROSCOPICUS VAR CRYSTALLOGENES, THE COPIAMYCIN SOURCE
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DOI：
10.7164/antibiotics.37.103
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发表时间：
1984-01-01
影响因子：
3.3
通讯作者：
FUKUSHIMA, K
中科院分区：
文献类型：
--
作者：
ARAI, T;UNO, J;FUKUSHIMA, K
S.吸水变种柯皮霉素来源crystalogenes产生了几种具有抗真菌活性的次要组分。这些次要成分之一，新卡匹霉素A，分离和表征。根据光谱学证据确定新柯帕霉素A的结构为N-去甲基柯帕霉素。该抗生素对革兰氏阳性菌和真菌的活性更高，但毒性低于柯皮霉素。
Fermentation of S. hygroscopicus var. crystallogenes, the copiamycin source, yielded several minor components with antifungal activity. One of these minor components, neocopiamycin A, was isolated and characterized. The structure of neocopiamycin A was determined as N-demethylcopiamycin on the basis of spectroscopic evidence. The antibiotic was more active against gram-positive bacteria and fungi, but less toxic than copiamycin.