Rising incidence of intrahepatic cholangiocarcinoma in the United States: a true increase?
Rising incidence of intrahepatic cholangiocarcinoma in the United States: a true increase?
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DOI：
10.1016/j.jhep.2003.11.030
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发表时间：
2004-03-01
影响因子：
25.7
通讯作者：
El-Serag, HB
中科院分区：
文献类型：
--
作者：
Shaib, YH;Davila, JA;El-Serag, HB
背景/目的：据报道，美国肝内胆管细胞癌（ICC）的发病率正在上升。本研究的目的是检查这是否是一个真正的增加或反映了改进的检测或reclassification.Methods：使用数据从监测流行病学和最终结果（SEER）计划，发病率为ICC之间的1975年和1999年进行了计算。我们还计算了每个肿瘤阶段的病例比例，显微镜下确诊的病例，以及生存率。在研究期间，ICC的发病率增加了165%。这一增长大部分发生在1985年以后。未分期癌、局限性癌、显微镜证实或肿瘤大小的患者比例无显著变化
Background/Aims: The incidence of intrahepatic cholangiocarcinoma (ICC) has been reported to be increasing in the USA. The aim of this study is to examine whether this is a true increase or a reflection of improved detection or reclassification.Methods: Using data from the Surveillance Epidemiology and End Results (SEER) program, incidence rates for ICC between 1975 and 1999 were calculated. We also calculated the proportions of cases with each tumor stage, microscopically confirmed cases, and the survival rates.Results: A total of 2864 patients with ICC were identified. The incidence of ICC increased by 165% during the study period. Most of this increase occurred after 1985. There were no significant changes in the proportion of patients with unstaged cancer, localized cancer, microscopic confirmation, or with tumor size