Prefrontal gray matter volume reduction in first episode schizophrenia
Prefrontal gray matter volume reduction in first episode schizophrenia
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DOI：
10.1093/cercor/11.4.374
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发表时间：
2001-04-01
期刊：
影响因子：
3.7
通讯作者：
McCarley, RW
中科院分区：
文献类型：
--
作者：
Hirayasu, Y;Tanaka, S;McCarley, RW
功能测量一直显示精神分裂症患者的前额叶异常。然而，结构磁共振成像（MRI）的结果前额叶体积减少一直不太一致。在这项研究中，我们评估了首次发病（首次住院）诊断为精神分裂症患者的前额叶灰质体积，并与首次发病诊断为情感性精神病的患者和正常对照组进行比较，以确定前额叶异常的存在和特异性。测量了首发精神分裂症患者（n = 17）、性别和父母社会经济状况匹配的情感性（主要是躁狂）精神病受试者（n = 17）和正常对照受试者（n = 17）的前额叶灰质和白色物质体积，这些受试者在狭窄的年龄范围（18-29岁）内年龄匹配。与首发情感性精神病和对照组相比，首发精神分裂症患者的总（左侧和右侧）前额叶灰质体积显著减少。随访分析表明，左前额叶灰质体积显著减少，右侧趋势水平降低。与对照组相比，精神分裂症患者左侧减少9.2%，右侧减少7.7%。各组之间的白色物质体积没有差异。这些数据表明，前额皮质灰质体积减少是选择性地出现在首次住院精神分裂症，但不是情感性精神病。
Functional measures have consistently shown prefrontal abnormalities in schizophrenia. However, structural magnetic resonance imaging (MRI) findings of prefrontal volume reduction have been less consistent. In this study, we evaluated prefrontal gray matter volume in first episode [first hospitalized) patients diagnosed with schizophrenia, compared with first episode patients diagnosed with affective psychosis and normal comparison subjects, to determine the presence in and specificity of prefrontal abnormalities to schizophrenia. Prefrontal gray and white matter volumes were measured from first episode patients with schizophrenia (n = 17), and from gender- and parental socio-economic status-matched subjects with affective (mainly manic) psychosis (n = 17) and normal comparison subjects (n = 17), age-matched within a narrow age range (18-29 years). Total (left and right) prefrontal gray matter volume was significantly reduced in first episode schizophrenia compared with first episode affective psychosis and comparison subjects. Follow-up analyses indicated significant left prefrontal gray matter volume reduction and trend level reduction on the right. Schizophrenia patients showed 9.2% reduction on the left and 7.7% reduction on the right compared with comparison subjects. White matter volumes did not differ among groups. These data suggest that prefrontal cortical gray matter Volume reduction is selectively present at first hospitalization in schizophrenia but not affective psychosis.