Gender differences in cerebellar metabolism: test-retest reproducibility.
Gender differences in cerebellar metabolism: test-retest reproducibility.
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DOI：
10.1176/ajp.154.1.119
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发表时间：
1997
期刊：
影响因子：
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通讯作者：
N. D. Volkow;Gene-Jack Wang;Joanna S. Fowler;R. Hitzemann;N. Pappas;K. Pascani;Christopher T. Wong
中科院分区：
文献类型：
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作者：
N. D. Volkow;Gene-Jack Wang;Joanna S. Fowler;R. Hitzemann;N. Pappas;K. Pascani;Christopher T. Wong
目的：本研究的目的是评估局部脑代谢基线测量的性别差异，并评估其可重复性。方法15名男性和13名女性健康受试者，平均年龄为44岁，在静息状态下进行正电子发射断层扫描和[18 F]氟脱氧葡萄糖（FDG）检查;其中8名男性和11名女性在相同条件下进行了第二次FDG扫描4-6周后，以评估先前结果的可重复性。结果女性和男性的全脑代谢无差异。在第一次评估中，女性受试者的颞极和小脑的代谢明显高于男性受试者。在第二次评估期间，女性受试者仅在小脑中具有显著更高的代谢。结论：本研究记录了小脑代谢的显著和可重复的性别差异;其功能意义值得进一步评价。
OBJECTIVE The purpose of this study was to evaluate gender differences in baseline measures of regional brain metabolism and to assess their reproducibility. METHOD Fifteen male and 13 female healthy subjects, whose mean age was 44 years, were tested with positron emission tomography and [18F]fluorodeoxyglucose (FDG) under resting conditions; eight of the men and 11 of the women underwent a second FDG scan under the same conditions 4-6 weeks later to assess the reproducibility of the previous results. RESULTS There were no differences in whole brain metabolism between the women and the men. In the first evaluation the female subjects showed significantly higher metabolism in the temporal poles and cerebellum than the male subjects. During the second evaluation the female subjects had significantly higher metabolism only in the cerebellum. CONCLUSIONS This study documents significant and reproducible gender differences in cerebellar metabolism; their functional significance merits further evaluation.