Correlations of degree of coronary artery stenosis with blood lipid, CRP, Hcy, GGT, SCD36 and fibrinogen levels in elderly patients with coronary heart disease
Correlations of degree of coronary artery stenosis with blood lipid, CRP, Hcy, GGT, SCD36 and fibrinogen levels in elderly patients with coronary heart disease
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DOI：
10.26355/eurrev_201911_19453
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发表时间：
2019-01-01
影响因子：
3.3
通讯作者：
Bai, L.
中科院分区：
文献类型：
--
作者：
Han, K.;Lu, Q.;Bai, L.
目的：探讨老年冠心病患者冠状动脉狭窄程度与血脂、C反应蛋白（CRP）、同型半胱氨酸（Hcy）、γ-谷氨酰转肽酶（GGT）、可溶性簇决定簇36（sCD36）、纤维蛋白原（Fib）水平的相关性。对观察组单支、双支、多支冠状动脉疾病患者和对照组正常人进行分析。比较两组血脂相关参数的变化，包括总胆固醇（TC）、三酰甘油（TG）、低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL-C）、CRP、Hcy、GGT、sCD36、Fib。分析Gensini评分与血液相关参数CRP、Hcy、GGT、sCD36、Fib变化的相关性。最后通过单因素和多因素logistic回归分析确定老年冠心病患者冠状动脉狭窄的危险因素。结果：多支、双支、单支冠心病冠心病患者的Gensini评分显着高于正常人（p
OBJECTIVE: To explore the correlations between the degree of coronary artery stenosis with blood lipid, C-reactive protein (CRP), homocysteine (Hcy), gamma-glutamyl transpeptidase (GGT), soluble cluster determinant 36 (sCD36), and fibrinogen (Fib) levels in elderly patients with coronary heart disease.PATIENTS AND METHODS: The Gensini scores for the coronary artery stenosis were analyzed in patients with single-vessel, double-vessel, and multi-vessel coronary artery diseases in observation group and normal people in control group. Changes in blood lipid-associated parameters, including total cholesterol (TC), triacylglycerol (TG), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C), CRP, Hcy, GGT, sCD36, and Fib were compared between the two groups. The correlations between the Gensini score with changes of the blood-associated parameters, CRP, Hcy, GGT, sCD36, and Fib were analyzed. Finally, univariate and multivariate logistic regression analyses were conducted to determine the risk factors for coronary artery stenosis in elderly patients with coronary heart disease.RESULTS: The Gensini score was significantly higher in coronary heart disease patients with multi-vessel, double-vessel, and single-vessel coronary artery diseases compared with that in normal people (p