Clean Photothermal Heating and Controlled Release from Near-Infrared Dye Doped Nanoparticles without Oxygen Photosensitization.
Clean Photothermal Heating and Controlled Release from Near-Infrared Dye Doped Nanoparticles without Oxygen Photosensitization.
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DOI：
10.1021/acs.langmuir.5b01878
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发表时间：
2015-07-21
期刊：
影响因子：
--
通讯作者：
Smith BD
中科院分区：
文献类型：
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作者：
Guha S;Shaw SK;Spence GT;Roland FM;Smith BD
将掺近红外Croc （Croc）染料的生物相容性有机纳米颗粒与掺常见近红外染料ICG和IR780的类似纳米颗粒的光热加热和释放性能进行了比较。脂质-聚合物-杂化纳米颗粒和脂质体的单独配方，每个都含有鳄鱼染料，在808 nm处被强烈吸收，并产生清洁的激光诱导加热（不产生1O2，也不产生染料的光漂白）。相比之下，激光诱导加热含有ICG或IR780的纳米颗粒会产生反应o2，导致染料漂白，并分解共封装的有效载荷，如药物阿霉素。鳄鱼染料是特别有用的光热剂激光控制释放的化学敏感载荷的纳米颗粒。溶液状态实验证明了水溶性荧光染料从热敏脂质体内部的重复分数释放。另外的实验使用聚焦激光束来控制固定脂质体的泄漏，具有很高的空间和时间精度。结果表明，掺杂Croc染料的纳米颗粒的分数光热泄漏是一种很有前途的控制释放应用的方法。
The photothermal heating and release properties of biocompatible organic nanoparticles, doped with a near-infrared croconaine (Croc) dye, were compared with analogous nanoparticles doped with the common near-infrared dyes ICG and IR780. Separate formulations of lipid-polymer-hybrid nanoparticles and liposomes, each containing Croc dye, absorbed strongly at 808 nm and generated clean laser-induced heating (no production of 1O2 and no photobleaching of the dye). In contrast, laser-induced heating of nanoparticles containing ICG or IR780 produced reactive 1O2 leading to bleaching of the dye and also decomposition of co-encapsulated payload such as the drug Doxorubicin. Croc dye was especially useful as a photothermal agent for laser controlled release of chemically sensitive payload from nanoparticles. Solution state experiments demonstrated repetitive fractional release of water soluble fluorescent dye from the interior of thermosensitive liposomes. Additional experiments used a focused laser beam to control leakage from immobilized liposomes with very high spatial and temporal precision. The results indicate that fractional photothermal leakage from nanoparticles doped with Croc dye is a promising method for a range of controlled release applications.