Understanding cytokine and growth factor receptor activation mechanisms.
Understanding cytokine and growth factor receptor activation mechanisms.
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DOI：
10.3109/10409238.2012.729561
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发表时间：
2012-11
影响因子：
6.5
通讯作者：
Whitty A
中科院分区：
文献类型：
--
作者：
Atanasova M;Whitty A
我们对细胞因子和生长因子受体详细作用机制的理解，尤其是对结构、机制和功能之间联系的定量理解，明显落后于我们对类似功能蛋白类别（如酶、G 蛋白偶联受体和离子通道）的了解。特别是，此类受体是否是通过配体诱导的寡聚化机制激活，还是通过配体与预先相关的受体二聚体或寡聚体结合并通过随后的构象重排激活的机制仍然存在争议。进展的一个主要限制是对活细胞内源水平表达的未修饰受体进行定量机制实验的方法相对缺乏。在本文中，我们回顾了细胞因子和生长因子受体激活机制的当前知识状况，批判性地评估了支持和反对不同提议机制的证据，并强调了其他尚未解答的关键问题。新的方法和技术导致该领域最近取得了快速进展，并且该领域有望在未来几年取得重大进展，这有望彻底改变我们对这一类在生物学和医学上都很重要的受体的理解。
Our understanding of the detailed mechanism of action of cytokine and growth factor receptors – and particularly our quantitative understanding of the link between structure, mechanism and function – lags significantly behind our knowledge of comparable functional protein classes such as enzymes, G protein-coupled receptors, and ion channels. In particular, it remains controversial whether such receptors are activated by a mechanism of ligand-induced oligomerization, versus a mechanism in which the ligand binds to a pre-associated receptor dimer or oligomer that becomes activated through subsequent conformational rearrangement. A major limitation to progress has been the relative paucity of methods for performing quantitative mechanistic experiments on unmodified receptors expressed at endogenous levels on live cells. In this article we review the current state of knowledge on the activation mechanisms of cytokine and growth factor receptors, critically evaluate the evidence for and against the different proposed mechanisms, and highlight other key questions that remain unanswered. New approaches and techniques have led to rapid recent progress in this area, and the field is poised for major advances in the coming years, which promises to revolutionize our understanding of this large and biologically and medically important class of receptors.
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影响因子：
4
作者：
Chen, Dianjun;Brahimi, Fouad;Burgess, Kevin
通讯作者：
Burgess, Kevin
DOI：
10.1038/2911
发表时间：
1998-11-01
期刊：
NATURE STRUCTURAL BIOLOGY
影响因子：
--
作者：
Ballinger, MD;Wells, JA
通讯作者：
Wells, JA
影响因子：
64.5
作者：
BANNER, DW;DARCY, A;LESSLAUER, W
通讯作者：
LESSLAUER, W
影响因子：
56.9
作者：
Boulanger, MJ;Chow, DC;Garcia, KC
通讯作者：
Garcia, KC
影响因子：
5.3
作者：
Colangelo, Anna Maria;Bianco, Maria Rosaria;Martegani, Enzo
通讯作者：
Martegani, Enzo