HEPATIC BILIRUBIN UDP-GLUCURONYL TRANSFERASE ACTIVITY IN LIVER DISEASE AND GILBERTS SYNDROME
HEPATIC BILIRUBIN UDP-GLUCURONYL TRANSFERASE ACTIVITY IN LIVER DISEASE AND GILBERTS SYNDROME
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DOI：
10.1056/nejm196906052802303
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发表时间：
1969-01-01
影响因子：
158.5
通讯作者：
BILLING, BH
中科院分区：
文献类型：
--
作者：
BLACK, M;BILLING, BH
最近描述的一种检测负责胆红素结合的特异性肝酶的方法被应用于剖腹或经皮针刺活检获得的肝脏标本。本文对79例实质性肝病、胆道梗阻和Gilbert综合征患者进行了研究，并与11例非肝病患者的结果进行了比较。在11例吉尔伯特综合征患者和4例肝豆状核变性患者中均观察到酶活性降低。胆道梗阻似乎导致该酶的活性增加。
A recently described method for assaying the specific hepatic enzyme responsible for the conjugation of bilirubin was applied to specimens of liver obtained at laparotomy or by percutaneous needle biopsy. Seventy-nine patients with parenchymatous liver disease, biliary obstruction or Gilbert's syndrome were studied, and the results obtained were compared with those from 11 patients without liver disease. A reduction in enzyme activity was observed in each of the 11 patients with Gilbert's syndrome, and in the four patients with Wilson's disease. Biliary obstruction appeared to cause an increase in the activity of the enzyme.