Heterosexually acquired CRF01_AE/B recombinant HIV type 1 found in Thailand.
Heterosexually acquired CRF01_AE/B recombinant HIV type 1 found in Thailand.
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泰国发现异性获得 CRF01_AE/B 重组 HIV 1 型。
DOI：
10.1089/08892220260387986
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发表时间：
2002
影响因子：
1.5
通讯作者：
S. Nitayaphan
中科院分区：
文献类型：
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作者：
Kwanjai Viputtijul;M. de Souza;R. Trichavaroj;J. Carr;S. Tovanabutra;F. McCutchan;S. Sriplienchan;P. Buapunth;C. Chuenchitra;J. McNeil;D. Birx;A. Brown;S. Nitayaphan
CRF01_AE和B亚型在泰国流行，这些毒株在一些高危人群中混合，这表明亚型间重组的可能性。最近鉴定了第一个这样的重组体，主要是来自CRF01_AE的具有gp120的B。在这里，我们报告了一个异源获得的重组体的不同结构，与大部分的基因组从CRF01_AE，但几乎整个包膜亚型B。通过多个地区的V3血清型和基因型监测，然后进行全基因组测序，以确定该菌株。在泰国进行的疫苗试验需要了解人群中是否存在这种毒株，这些重组体为实验室评估交叉亚型免疫力提供了有价值的试剂。研究正在进行中，以确定是否重组广泛传播。
CRF01_AE and subtype B are circulating in Thailand and the strains have become intermixed in some high-risk groups, establishing the possibility of intersubtype recombination. The first such recombinant, mostly B with gp120 from CRF01_AE, was recently identified. Here we report a heterosexually acquired recombinant of different structure, with most of the genome from CRF01_AE but almost the entire envelope from subtype B. Surveillance by V3 serotype and genotype in multiple regions, followed by full-genome sequencing, was used to identify this strain. Pending vaccine trials in Thailand require knowledge of the presence of such strains in the population, and these recombinants provide valuable reagents for the laboratory evaluation of cross-subtype immunity. Studies are underway to determine whether either recombinant is circulating widely.