Evidence that Armadillo transduces Wingless by mediating nuclear export or cytosolic activation of Pangolin (Retracted Article. See vol 116, pg 481, 2004)
Evidence that Armadillo transduces Wingless by mediating nuclear export or cytosolic activation of Pangolin (Retracted Article. See vol 116, pg 481, 2004)
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DOI：
10.1016/s0092-8674(02)01037-1
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发表时间：
2002-10-18
期刊：
影响因子：
64.5
通讯作者：
Struhl, G
中科院分区：
文献类型：
--
作者：
Chan, SK;Struhl, G
Wnt家族的分泌蛋白在动物发育过程中起着重要的组织作用，并通过Frizzled型(FZ)类跨膜受体和Tcf/Lef/穿山甲类转录因子的活性进行转导。β-连环素，包括果蝇Armadillo(ARM)，将细胞表面FZ的激活与细胞核内TCF的转录调控联系起来。普遍的观点是Wnt信号诱导β-catenin进入细胞核，并与Tcf结合形成转录因子复合体，其中Tcf与DNA结合，β-catenin的C-末端结构域激活转录。在这里，我们提出了挑战这一观点的发现，并建议R-catenin可能通过从细胞核输出TCF或在细胞质中激活它来转导Wnt信号。
Secreted proteins of the Wnt family have profound organizing roles during animal development and are transduced via the activities of the Frizzled (Fz) class of transmembrane receptors and the TCF/LEF/Pangolin class of transcription factors. beta-catenins, including Drosophila Armadillo (Arm), link activation of Fz at the cell surface to transcriptional regulation by TCF in the nucleus. The consensus view is that Wnt signaling induces beta-catenin to enter the nucleus and combine with TCF to form a transcription factor complex in which TCF binds DNA and the C-terminal domain of beta-catenin activates transcription. Here, we present findings, which challenge this view and suggest instead that R-catenin may transduce Wnt signals by exporting TCF from the nucleus or activating it in the cytoplasm.