Development of fatness, fitness, and lifestyle from adolescence to the age of 36 years - Determinants of the metabolic syndrome in young adults: The Amsterdam growth and health longitudinal study
Development of fatness, fitness, and lifestyle from adolescence to the age of 36 years - Determinants of the metabolic syndrome in young adults: The Amsterdam growth and health longitudinal study
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DOI：
10.1001/archinte.165.1.42
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发表时间：
2005-01-10
影响因子：
--
通讯作者：
Stehouwer, CDA
中科院分区：
文献类型：
--
作者：
Ferreira, I;Twisk, JWR;Stehouwer, CDA
背景：在年轻人中，代谢综合征是心血管疾病的一个日益频繁的危险因素。然而，人们对它的决定因素并不完全了解。我们调查了364名个体(189名女性)从青春期(13岁)到成年期(36岁)的重要潜在决定因素(体脂和脂肪分布、心肺健康和生活方式)的时间进程。方法：数据来自阿姆斯特丹生长与健康纵向研究，并使用广义估计方程进行分析。结果：根据国家胆固醇教育计划修改后的代谢综合征定义，36岁时代谢综合征的患病率为10.4%。36岁有代谢综合征的受试者与未患代谢综合征的受试者相比，(从青春期到36岁)有以下几个方面：(1)总体体脂和躯干皮下脂肪增加更明显；(2)心肺健康水平下降更明显；(3)轻到中等强度的体力活动增加更明显，但硬体力活动减少更明显；(4)全年能量摄入量有增加的趋势；结论：肥胖、健康和生活方式是年轻人代谢综合征的重要决定因素。更重要的是，这些关联是相互独立的，因此代表着预防代谢综合征的单独的潜在靶点。我们的研究进一步表明，在生命的早期(例如，从青春期到成年期的过渡时期)进行干预可能是预防代谢综合征的有效领域。
Background: Among young adults, the metabolic syndrome is an increasingly frequent risk factor for cardiovascular disease. Its determinants are, however, incompletely understood. We investigated the time course, from adolescence (age, 13 years) to young adulthood (age, 36 years), of important potential determinants (body fatness and fat distribution, cardiopulmonary fitness, and lifestyle) in 364 individuals (189 women).Methods: Data were derived from the Amsterdam Growth and Health Longitudinal Study and analyzed with the use of generalized estimating equations.Results: The prevalence of the metabolic syndrome at the age of 36 years, as identified with a modified National Cholesterol Education Program definition of the syndrome, was 10.4%. Subjects with the metabolic syndrome at the age of 36 years, compared with those without the syndrome, had (from adolescence to the age of 36 years) the following: (1) a more marked increase in total body fatness and in subcutaneous trunk fat; (2) a more marked decrease in cardiopulmonary fitness levels; (3) a more marked increase inphysical activities of light-to-moderate intensity, but a more marked decrease in hard physical activities; (4) a trend toward a higher energy intake throughout the years; and (5) a decreased likelihood of drinking alcoholic beverages.Conclusions: Fatness, fitness, and lifestyle are important determinants of the metabolic syndrome in young adults. More important, these associations were independent of each other and, therefore, represent separate potential targets for the prevention of the metabolic syndrome. Our study further suggests that intervening early in life (eg, in the period of transition from adolescence to adulthood) may be a fruitful area for prevention of the metabolic syndrome.