The epidemic of esophageal adenocarcinoma
The epidemic of esophageal adenocarcinoma
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DOI：
10.1016/s0889-8553(02)00016-x
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发表时间：
2002-06-01
影响因子：
3.7
通讯作者：
El-Serag, HB
中科院分区：
文献类型：
--
作者：
El-Serag, HB
过去 2 到 3 年来，美国、几个欧洲国家和大洋洲与食管腺癌 (EAC) 相关的发病率和死亡率一直在增加。生存率仍然很低，同期几乎没有改善。胃食管恶性肿瘤的编码、分类和检测的变化可能部分促成了观察到的趋势。 EAC 的流行病学特征与性别、种族和地理相关，存在显着差异。胃食管反流病 (GERD) 是 Barrett 食管的主要危险因素，而 Barrett 食管是 EAC 唯一已知的前兆病变。人们提出了一些促进胃食管反流病和/或巴雷特食管发展的危险因素来解释这些上升趋势；这些因素包括幽门螺杆菌感染率下降、肥胖、饮食因素和某些药物。
The incidence and mortality related to esophageal adenocarcinoma (EAC) have been increasing in the United States, several European countries, and Oceania for the past 2 to 3 decades. Survival remains dismal, with little improvement during the same time period. Variations in the coding, classification, and detection of gastroesophageal malignancy may have contributed partially to the observed trends. Remarkable differences related to gender, ethnicity, and geography characterize the epidemiology of EAC. Gastroesophageal reflux disease (GERD) is the main risk factor for Barrett's esophagus, which is the only known precursor lesion for EAC. Several risk factors that promote the development of GERD and/or Barrett's esophagus have been proposed to explain these rising trends; these factors include the declining rates of Helicobactcr pylori infection, obesity, dietary factors, and certain drugs.