Alpiniae oxyphyllae Fructus and Alzheimer's disease: An update and current perspective on this traditional Chinese medicine
Alpiniae oxyphyllae Fructus and Alzheimer's disease: An update and current perspective on this traditional Chinese medicine
复制标题
益智仁与阿尔茨海默病：传统中药的更新和当前观点。
DOI：
10.1016/j.biopha.2020.111167
复制
发表时间：
2021-03-01
影响因子：
7.5
通讯作者：
Sun, Zhi
中科院分区：
文献类型：
--
作者：
Li, Jia;Du, Qiuzheng;Sun, Zhi
阿尔茨海默病(AD)是一种常见的进行性神经退行性疾病，其发病率和死亡率仍呈上升趋势。尽管最近在治疗AD方面取得了一些进展，但它们的临床疗效有限，无法治愈，而且容易产生耐药性。益智是从姜科植物益智的干燥成熟果实中提取的植物，是治疗阿尔茨海默病的首选中药，具有较好的疗效，已被长期使用。最近的研究表明，它在调节与11-淀粉样蛋白沉积、tau蛋白磷酸化、慢性炎症、氧化应激相关的多个信号通路方面具有强大的活性。AOF在阿尔茨海默病中的神经药理机制已被大量研究充分阐明。在这篇综述中，我们首先简要介绍了AOF的活性成分及其治疗AD的相关机制。并系统综述了AOF活性成分药代动力学特征的研究进展，分析了AOF活性成分在AD发病过程中的生物利用度差异。因此，AOF在治疗AD方面具有很大的治疗潜力，值得进一步研究和推广。
Alzheimer's disease (AD) is a common progressive neuro-degenerative disease, and the morbidity and mortality are still on the rise. In spite of recent advances in AD treatment, their clinical efficacy has been limited, non curative and easy to drug resistance. Alpiniae oxyphyllae Fructus (AOF), derived from the dried and mature fruits of the Zingiberaceae plant Alpinia oxyphylla Miq, is a choice in traditional Chinese medicine to treat AD, which has a good effect and has been used for a long time. Recent studies have demonstrated its potent activities in modulating multiple signaling pathways associated with ll-amyloid deposition, tau protein phosphorylation, chronic inflammation, oxidative stress. The neuropharmacological mechanism of AOF in AD have been fully illustrated in numerous studies. In this review, we first briefly described the active components of AOF and related mechanism for treating AD. And we also provide a systematic overview of recent progress on the pharmacokinetic characteristics of the active ingredients of AOF and analyzed their bioavailability differences in the development of AD. Thus, AOF hold a great therapeutic potential in the treatment of AD and is worthy of further research and promotion.