Infrared spectroscopy in hemodialysis: reagent-free monitoring of patient detoxification by infrared spectroscopy
Infrared spectroscopy in hemodialysis: reagent-free monitoring of patient detoxification by infrared spectroscopy
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血液透析中的红外光谱：通过红外光谱无需试剂监测患者的排毒情况
DOI：
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发表时间：
2012
影响因子：
4.3
通讯作者：
W. Mäntele
中科院分区：
文献类型：
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作者：
A. Roth;Fabian Dornuf;Oliver Klein;D. Schneditz;H. Hafner‐Giessauf;W. Mäntele
本文报道了一种基于红外光谱定量测定血液透析中透析分子的血液透析监测方法。测量不含试剂，旨在对血液透析患者进行实时和在线监测。使用衰减全反射红外光谱法的流动池连接在透析过滤器单元的下游。通过化学参比分析和人工混合透析样品分析，建立了真实的血液透析样品的校准模型。血液透析的红外监测包括定量测定作为主要物质的尿素以及葡萄糖、乳酸盐和肌酐，所有这些的精确度仅受化学参比分析的限制。该流动池可安装在所有标准血液透析系统上。对血液透析患者的初步试验表明，解毒可以清楚地监测。此外，这些实验表明，患者的生理参数的广泛的，实时的控制是可能的，这种方法，这可能会导致增加患者的安全性。
图血液透析中的红外光谱：透析和测量原理
AbstractA method for monitoring hemodialysis based on quantitative infrared spectroscopic determination of the molecules dialyzed from patient blood is reported. The measurements are reagent-free and aim at real-time and in-line monitoring of the hemodialysis patient. A flow cell using attenuated total reflection infrared spectroscopy is coupled downstream of the dialysis filter unit. A calibration model has been developed from real hemodialysis samples analyzed by chemical reference analysis and from artificially mixed dialysis samples. The infrared monitoring of hemodialysis includes quantitative determination of urea as the lead substance, as well as glucose, lactate, and creatinine, all at a precision only limited by the chemical reference analysis. The flow cell can be fitted to all standard hemodialysis systems. Preliminary tests with hemodialysis patients have demonstrated that detoxification can be clearly monitored. Furthermore, these experiments demonstrate that a wide, real-time control of the patient’s physiological parameters is possible with this method, which could lead to increased patient safety.
FigureInfrared Spectroscopy in hemodialysis: Dialysis and measuring principle