Oxidative stress in severe acute illness.
Oxidative stress in severe acute illness.
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DOI：
10.1016/j.redox.2015.01.006
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发表时间：
2015
期刊：
影响因子：
11.4
通讯作者：
Brody, Edward N.
中科院分区：
文献类型：
--
作者：
Bar-Or, David;Bar-Or, Raphael;Rael, Leonard T.;Brody, Edward N.
关键词：
细胞的总体氧化还原电位主要由可氧化/可还原的化学对决定，包括谷胱甘肽-谷胱甘肽二硫化物、还原型硫氧还蛋白-氧化型硫氧还蛋白和NAD+-NADH（和NADP-NADPH）。目前用于评估氧化应激的方法依赖于检测氧化损伤的个体副产物的水平或通过测定个体抗氧化酶的总水平或活性。另一方面，氧化还原电位（ORP）是生物系统中总（已知和未知）促氧化剂和抗氧化剂组分之间平衡的综合全面测量。氧化应激在阿尔茨海默病和动脉粥样硬化等慢性疾病中的作用已受到广泛重视。氧化应激在急诊室和重症监护室常见的急性疾病中的作用相当大。新的工具，快速，廉价的测量氧化还原电位和总氧化还原能力，应有助于引进一个新的机构的文献氧化应激在急性疾病中的作用，以及如何筛选和监测潜在的有益的药理剂。
The overall redox potential of a cell is primarily determined by oxidizable/reducible chemical pairs, including glutathione–glutathione disulfide, reduced thioredoxin–oxidized thioredoxin, and NAD+–NADH (and NADP–NADPH). Current methods for evaluating oxidative stress rely on detecting levels of individual byproducts of oxidative damage or by determining the total levels or activity of individual antioxidant enzymes. Oxidation–reduction potential (ORP), on the other hand, is an integrated, comprehensive measure of the balance between total (known and unknown) pro-oxidant and antioxidant components in a biological system. Much emphasis has been placed on the role of oxidative stress in chronic diseases, such as Alzheimer's disease and atherosclerosis. The role of oxidative stress in acute diseases often seen in the emergency room and intensive care unit is considerable. New tools for the rapid, inexpensive measurement of both redox potential and total redox capacity should aid in introducing a new body of literature on the role of oxidative stress in acute illness and how to screen and monitor for potentially beneficial pharmacologic agents.
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DOI：
10.1042/bj20081386
发表时间：
2009-01-01
期刊：
The Biochemical journal
影响因子：
--
作者：
Murphy MP
通讯作者：
Murphy MP
影响因子：
7.4
作者：
Manevich, Y.;Hutchens, S.;Halushka, P. V.;Tew, K. D.;Townsend, D. M.;Jauch, E. C.;Borg, K.
通讯作者：
Borg, K.
影响因子：
56.9
作者：
HWANG, C;SINSKEY, AJ;LODISH, HF
通讯作者：
LODISH, HF
影响因子：
2.7
作者：
McKinlay A;Gerard W;Fields S
通讯作者：
Fields S
影响因子：
64.8
作者：
Chouchani, Edward T.;Pell, Victoria R.;Gaude, Edoardo;Aksentijevic, Dunja;Sundier, Stephanie Y.;Robb, Ellen L.;Logan, Angela;Nadtochiy, Sergiy M.;Ord, Emily N. J.;Smith, Anthony C.;Eyassu, Filmon;Shirley, Rachel;Hu, Chou-Hui;Dare, Anna J.;James, Andrew M.;Rogatti, Sebastian;Hartley, Richard C.;Eaton, Simon;Costa, Ana S. H.;Brookes, Paul S.;Davidson, Sean M.;Duchen, Michael R.;Saeb-Parsy, Kourosh;Shattock, Michael J.;Robinson, Alan J.;Work, Lorraine M.;Frezza, Christian;Krieg, Thomas;Murphy, Michael P.
通讯作者：
Murphy, Michael P.