Inhibition of proteinuria development in aging Sprague-Dawley rats and C57BL/6 mice by long-term treatment with dehydroepiandrosterone.
Inhibition of proteinuria development in aging Sprague-Dawley rats and C57BL/6 mice by long-term treatment with dehydroepiandrosterone.
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长期用脱氢表雄酮治疗可抑制衰老 Sprague-Dawley 大鼠和 C57BL/6 小鼠蛋白尿的发生。
DOI：
10.1093/geronj/41.4.433
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发表时间：
1986
期刊：
影响因子：
--
通讯作者：
Schwartz,AG
中科院分区：
文献类型：
--
作者：
Pashko,LL;Fairman,DK;Schwartz,AG
脱氢表雄酮(DHEA)是一种肾上腺类固醇，此前已被证明在实验室啮齿动物身上具有抗肥胖、抗糖尿病、癌症预防和抗自身免疫作用。当DHEA从2个月大的雄性SD大鼠开始在饮食中给予时，在19个月时抑制蛋白尿的发展。未接受治疗的大鼠的尿蛋白排泄量是接受DHEA治疗的大鼠的6.5倍。DHEA的部分作用显然是由于处理组大鼠减少了食物摄入量(减少了14%)，但这不能单独解释它的作用，因为成对喂养组的尿蛋白排泄量明显高于DHEA处理组(2.3倍)。在17个月大的雄性C57BL/6小鼠中，10月龄开始的DHEA治疗对蛋白尿产生了类似的抑制作用(尿蛋白排泄量是非DHEA治疗小鼠的5.8倍)。DHEA治疗使C57BL/6小鼠的摄食量减少了11%。这种食物摄入量的减少对蛋白尿没有明显的影响，因为发现配对喂养的一组小鼠的尿蛋白排泄量是DHEA治疗组的6.5倍。
Dehydroepiandrosterone (DHEA) is an adrenal steroid that previously has been shown to produce antiobesity, antidiabetic, cancer preventive, and antiautoimmune effects in laboratory rodents. DHEA, when administered in the diet to male Sprague-Dawley rats beginning at 2 months of age, inhibited the development of proteinuria at 19 months. The nontreated rats excreted 6.5 times as much urinary protein as the group treated with DHEA. Part of the effect of DHEA is apparently a result of reduced food intake in the treated rats (14% reduction), but this alone could not account for its action as a pair-fed group excreted significantly more urinary protein than the DHEA treated rats (2.3 times as much). A similar inhibition of proteinuria in 17-month-old male C57BL/6 mice was produced by DHEA treatment initiated at 10 months of age (5.8 times as much urinary protein excreted by non-DHEA treated mice). DHEA treatment reduced food intake by 11% in the C57BL/6 mice. This reduction in food intake had no apparent effect on proteinuria since a pair-fed group was found to excrete 6.5 times the amount of urinary protein as the DHEA-treated mice.