Bulk, surface properties and water uptake mechanisms of salt/acid amorphous composite systems
Bulk, surface properties and water uptake mechanisms of salt/acid amorphous composite systems
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DOI：
10.1016/j.ijpharm.2013.07.076
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发表时间：
2013-11-01
影响因子：
5.8
通讯作者：
Healy, Anne Marie
中科院分区：
文献类型：
--
作者：
Bianco, Stefano;Tewes, Frederic;Healy, Anne Marie
Developing amorphous pharmaceuticals can be desirable due to advantageous biopharmaceutical properties. Low glass transition temperature (T-g) amorphous drugs can be protected from crystallisation by mixing with high T-g excipients, such as polymers, or with salt forms. However, both polymers and salts can enhance the water uptake. The aim of this study was to formulate physico-chemically stable amorphous materials, by co-processing different proportions of sulfathiazole and its sodium salt to produce an optimum ratio, characterised by the best physical stability and lowest hygroscopicity. Both sulfathiazole and salt amorphised upon spray drying. At room temperature, sulfathiazole crystallised within 1h at
