Natural history and functional divergence of protein tyrosine kinases.
Natural history and functional divergence of protein tyrosine kinases.
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DOI：
10.1016/s0378-1119(03)00696-6
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发表时间：
2003-10
期刊：
影响因子：
3.5
通讯作者：
Jianying Gu;X. Gu
中科院分区：
文献类型：
--
作者：
Jianying Gu;X. Gu
细胞信号传导对于许多生物过程非常重要，包括生长、分化、粘附、运动和凋亡。蛋白酪氨酸激酶（PTK）超基因家族是后生动物细胞信号转导的关键介质，与多种人类疾病直接相关。尽管多结构域结构可变，但所有 PTK 都包含高度保守的催化激酶结构域。在每个 PTK 基因家族中，成员在底物特异性或时间/组织特异性表达方面表现出功能差异，尽管它们的主要功能是保守的。对主要PTK基因家族进行系统发育分析后，我们发现每个PTK家族的扩展很可能是由硬骨鱼出现之前、脊椎动物-文昌鱼分裂之后发生的基因或基因组复制事件引起的。我们进一步研究了这些基因家族中基因复制后功能分歧的进化模式。我们的结果表明，位点特异性转移进化速率（改变功能约束）是 PTK 基因家族进化的常见模式。
Cellular signaling is important for many biological processes including growth, differentiation, adhesion, motility and apoptosis. The protein tyrosine kinase (PTK) supergene family is the key mediator in cellular signaling in metazoans, directly associated with a variety of human diseases. All PTKs contain a highly conserved catalytic kinase domain, in spite of variable multi-domain structures. Within each PTK gene family, members exhibit functional divergence in substrate-specificity or temporal/tissue-specific expression, although their primary function is conserved. After conducting phylogenetic analysis on major PTK gene families, we found that the expanding of each PTK family was likely caused by gene or genome duplication event(s) that occurred before the emergence of teleosts but after the vertebrate–amphioxus split. We further investigated the evolutionary pattern of functional divergence after gene duplication in those gene families. Our results show that site-specific shifted evolutionary rate (altered functional constraint) is a common pattern in PTK gene family evolution.