Interoceptive awareness changes the posterior insula functional connectivity profile
Interoceptive awareness changes the posterior insula functional connectivity profile
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DOI：
10.1007/s00429-015-0989-8
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发表时间：
2016-04-01
影响因子：
3.1
通讯作者：
Schuetz-Bosbach, Simone
中科院分区：
文献类型：
--
作者：
Kuehn, Esther;Mueller, Karsten;Schuetz-Bosbach, Simone
内感意识描述了有意识地感知身体内部信号的能力，比如一个人自己的心跳。这种能力被认为是由右前岛来调节的。在这方面，后岛的作用，特别是从后岛到前岛的信号流的作用还不是很清楚。我们使用3T功能磁共振扫描了27名具有高或低相互感觉意识的健康人，同时他们要么监测自己的心跳，要么分别监测外部音调。我们使用网络中心性和双变量连通性分析相结合的方法，分别描述了在内感知觉和外感知觉过程中后岛和前岛之间皮质信号流的变化。我们发现心跳监测伴随着右后岛网络中心性降低，右后岛与右中前岛之间的功能连接强度降低。此外，在感觉间知觉过程中，右侧后岛叶和双侧扣带回前皮质以及双侧眶前叶皮质之间的信号流动减少。功能连接性的改变只表现在具有高相互感觉意识的人身上，并且特别发生在低频范围内(即<；0.1赫兹)。在休息期间，两组人的功能连接性特征没有差异。我们的结果首次表明，内感知觉在低频率范围内改变了岛内的信号流。我们推测，在内感觉知过程中，选择性地抑制从后到前岛通路上的缓慢信号进程，可以显著而无声地检测到自己的心跳。
Interoceptive awareness describes the ability to consciously perceive inner bodily signals, such as one's own heartbeat. The right anterior insula is assumed to mediate this ability. The role of the posterior insula, particularly posterior-to-anterior insula signal flows is less clear in this respect. We scanned 27 healthy people with either high or low interoceptive awareness using 3T fMRI, while they either monitored their own heartbeats, or external tones, respectively. We used a combination of network centrality and bivariate connectivity analyses to characterize changes in cortical signal flows between the posterior insula and the anterior insula during interoceptive awareness or exteroceptive awareness, respectively. We show that heartbeat monitoring was accompanied by reduced network centrality of the right posterior insula, and decreased functional connectivity strengths between the right posterior insula and the right mid and anterior insula. In addition, decreased signal flows between the right posterior insula and the bilateral anterior cingulate cortices, and the bilateral orbitofrontal cortices were observed during interoceptive awareness. Functional connectivity changes were only shown by people with high interoceptive awareness, and occurred specifically within the low-frequency range (i.e., < 0.1 Hz). Both groups did not differ in their functional connectivity profiles during rest. Our results show for the first time that interoceptive awareness changes intra-insula signal flows in the low-frequency range. We speculate that the selective inhibition of slow signal progression along the posterior-to-anterior insula pathway during interoceptive awareness allows the salient and noiseless detection of one's own heartbeat.