Abnormally High Blood Acetaldehyde Concentrations Suggest Potential Postmortem Ethanol Generation
Abnormally High Blood Acetaldehyde Concentrations Suggest Potential Postmortem Ethanol Generation
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血液乙醛浓度异常高表明死后可能产生乙醇
DOI：
10.1093/jat/bkaa173
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发表时间：
2021
影响因子：
2.5
通讯作者：
Jiang Yan
中科院分区：
文献类型：
--
作者：
Chen Xiaomin;Dong Xiaoru;Zhu Rongzhe;Xue Qiupeng;Zhang Dingang;Liu Xiaochen;Zheng Lixing;Jiang Yan
乙醇是全世界最常用和滥用的物质之一。确定尸体中检测到的乙醇来源是生前摄入还是死后生成对于确定死因尤其重要，这仍然是一个充满活力的研究领域。尸体腐败过程中合成乙醇的过程中，还会产生乙醛、正丙醇等其他小分子物质。根据我们对法医案件真实样本的前瞻性统计分析，当血液中检测到的乙醛浓度超过0.014 g/dL时，可以合理地怀疑死后产生乙醇。通过体外模拟实验，除了证实乙基葡萄糖醛酸和乙基硫酸盐是死前摄入乙醇的可靠生物标志物外，我们还提出乙醛作为尸体血液中死后乙醇形成的潜在标志物比正丙醇更敏感。
Ethanol is one of the most commonly used and abused substances worldwide. Identifying whether the source of ethanol detected in corpses is antemortem ingestion or postmortem generation is especially important for determining the cause of death, which remains a vibrant field of research. During the synthesis of ethanol in the putrefaction process of corpses, other small molecules such as acetaldehyde andn-propanol could also be produced. According to our prospective statistical analysis based on authentic samples from forensic cases, it is rational to suspect ethanol generation after death when the concentration of acetaldehyde detected in blood exceeds 0.014 g/dL. Throughin vitrosimulation experiments, in addition to confirming that ethyl glucuronide and ethyl sulfate are the reliable biomarkers of antemortem ingestion of ethanol, we propose that acetaldehyde is far more sensitive thann-propanol as a potential marker in the blood of corpses for postmortem ethanol formation.