Outdoor air pollution and asthma.
Outdoor air pollution and asthma.
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DOI：
10.1016/s0140-6736(14)60617-6
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发表时间：
2014-05-03
期刊：
影响因子：
168.9
通讯作者：
Balmes, John R.
中科院分区：
文献类型：
--
作者：
Guarnieri, Michael;Balmes, John R.
交通和发电是城市空气污染的主要来源。室外空气污染可能导致既存哮喘恶化的观点得到了几十年来积累的证据基础的支持，几项研究表明，室外空气污染也会导致新发哮喘。在本系列论文中，我们讨论了颗粒物（PM），气体污染物（臭氧，二氧化氮和二氧化硫）以及混合交通相关空气污染的影响。我们专注于临床研究，流行病学和实验，在过去5年发表。从机理的角度来看，空气污染物可能会对气道造成氧化损伤，导致炎症，重塑和致敏风险增加。虽然有几种污染物与新发哮喘有关，但证据的强度是可变的。我们还讨论了空气污染和哮喘相关的临床意义，政策问题和研究空白。
Traffic and power generation are the main sources of urban air pollution. The idea that outdoor air pollution can cause exacerbations of pre-existing asthma is supported by an evidence base that has been accumulating for several decades, with several studies suggesting a contribution to new-onset asthma as well. In this Series paper, we discuss the effects of particulate matter (PM), gaseous pollutants (ozone, nitrogen dioxide, and sulphur dioxide), and mixed traffic-related air pollution. We focus on clinical studies, both epidemiological and experimental, published in the previous 5 years. From a mechanistic perspective, air pollutants probably cause oxidative injury to the airways, leading to inflammation, remodelling, and increased risk of sensitisation. Although several pollutants have been linked to new-onset asthma, the strength of the evidence is variable. We also discuss clinical implications, policy issues, and research gaps relevant to air pollution and asthma.