Role of carbon monoxide in heme-induced vasodilation.
Role of carbon monoxide in heme-induced vasodilation.
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DOI：
10.1016/s0014-2999(97)00145-3
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发表时间：
1997-04
影响因子：
5
通讯作者：
F. Kozma;Robert A. Johnson;A. Nasjletti
中科院分区：
文献类型：
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作者：
F. Kozma;Robert A. Johnson;A. Nasjletti
我们研究了一氧化碳和血红素-l-赖氨酸盐对离体加压股薄肌小动脉直径的影响。两种药物均增加小动脉直径。血红素加氧酶抑制剂可以阻止血红素-l-赖氨酸盐的血管扩张作用，但一氧化碳的血管扩张作用却不能阻止。因此，血红素-L-赖氨酸诱导的血管舒张似乎是由血管血红素代谢产物介导的，推测为一氧化碳。这意味着一氧化碳的血管形成可能有助于血管舒张功能。
We investigated the effects of carbon monoxide and heme-l-lysinate on the diameter of isolated, pressurized gracilis muscle arterioles. Both agents increased arteriolar diameter. The vasodilatory effect of heme-l-lysinate, but not of carbon monoxide was prevented by an inhibitor of heme oxygenase. Hence, heme-l-lysinate-induced vasodilation appears to be mediated by a product of vascular heme metabolism, presumably carbon monoxide. This implies that vascular formation of carbon monoxide may subserve a vasodilatory function.