CORTICAL TEMPERATURE AND EEG SLOW-WAVE ACTIVITY IN THE RAT - ANALYSIS OF VIGILANCE STATE RELATED CHANGES
CORTICAL TEMPERATURE AND EEG SLOW-WAVE ACTIVITY IN THE RAT - ANALYSIS OF VIGILANCE STATE RELATED CHANGES
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DOI：
10.1007/bf00374625
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发表时间：
1992-04-01
影响因子：
4.5
通讯作者：
BORBELY, AA
中科院分区：
文献类型：
--
作者：
FRANKEN, P;TOBLER, I;BORBELY, AA
在睡眠剥夺（SD）24 h后的一个基线日和两个恢复日（恢复1和2）连续记录10只大鼠的警觉状态、皮层温度（T（CRT））和脑电图（EEG）慢波活动（SWA，0.75-4.0 Hz范围内的平均功率密度）。分析了非快速眼动睡眠（NREMS）、快速眼动睡眠（REMS）和清醒（W）以及警觉状态转换时T（CRT）的短期变化。在NREMS发作期间和W向NREMS（WN）转换时分析SWA。T（CRT）在W和REMS发作期间增加，在NREMS发作期间减少。这些变化是发作持续时间的函数，对于W和NREMS，也是发作开始时T（CRT）的函数。在恢复1中，NREMS至REMS（NR）和NREMS至W（NW）转换时的T（CRT）增加趋于减弱。SD后NREMS发作的SWA增强。在所有实验日内，NREMS发作时SWA的增加与T（CRT）的减少不相关，因此，在SD恢复过程中，状态转换时T（CRT）的变化几乎不受影响。T（CRT）和SWA的变化之间缺乏相关性，这表明大脑温度和睡眠强度的调节是独立的机制。
Vigilance states, cortical temperature (T(CRT)), and electroencephalograph (EEG) slow-wave-activity (SWA, mean power density in the 0.75-4.0 Hz range) of ten rats were recorded continuously during a baseline day, and two recovery days (Recovery 1 and 2) after 24 h of sleep deprivation (SD). The short term changes of T(CRT) were analysed within episodes of nonrapid eye movement sleep (NREMS), REM sleep (REMS) and waking (W), and at transitions between vigilance states. SWA was analysed within NREMS episodes and at W to NREMS (WN) transitions.T(CRT) increased during episodes of W and REMS, and decreased during NREMS episodes. These changes were a function of episode duration, and, for W and NREMS, of T(CRT) at episode onset. In Recovery 1 the increase in T(CRT) at NREMS to REMS (NR) and NREMS to W (NW) transitions tended to be attenuated. SWA within NREMS episodes was enhanced after SD. Over all experimental days, the increase of SWA and the decrease of T(CRT) in NREMS episodes were not correlated.It is concluded that during recovery from SD the changes in T(CRT) at state transitions were little affected. The lack of a relationship between changes in T(CRT) and SWA indicates that separate mechanisms underlie the regulation of brain temperature and sleep intensity.