Patterns of smell recovery in 751 patients affected by the COVID-19 outbreak
Patterns of smell recovery in 751 patients affected by the COVID-19 outbreak
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DOI：
10.1111/ene.14440
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发表时间：
2020-08-05
影响因子：
5.1
通讯作者：
Saussez, S.
中科院分区：
文献类型：
--
作者：
Chiesa-Estomba, C. M.;Lechien, J. R.;Saussez, S.
背景和目的：病毒后嗅觉功能障碍已被广泛证实，并已被证明是 COVID-19 的一个关键症状，超过 66% 的欧洲和美国患者报告有一定程度的嗅觉丧失。持续性嗅觉功能障碍似乎很常见，并将推动未来几个月对全科医生、耳鼻喉科或神经科咨询的需求——有关康复的证据对于为患者提供咨询至关重要。方法：这是一项基于前瞻性调查的数据收集和远程医疗随访。结果：总共有 751 名患者完成了研究，其中 477 名女性和 274 名男性。患者的平均年龄为 41 +/- 13 岁（范围 18-60 岁）。有 621 名患者（83%）主观报告嗅觉完全丧失，130 名患者（17%）主观报告嗅觉部分丧失。自第一次咨询起平均随访 47 +/- 7 天（范围 30-71）后，277 名 (37%) 患者仍报告持续主观嗅觉丧失，107 名 (14%) 患者报告部分恢复，367 名 (49%) 患者报告完全恢复。完全康复的患者嗅觉功能障碍的平均持续时间为 10 +/- 6 天（范围 3-31），部分恢复的患者嗅觉功能障碍的平均持续时间为 12 +/- 8 天（范围 7-35）。结论：根据我们的结果，在大流行的相对早期阶段，COVID-19 患者嗅觉功能障碍恢复的主观模式对于我们的患者、假设的生成和研究都很有价值。 治疗的发展。
Background and purpose: Post-viral olfactory dysfunction is well established and has been shown to be a key symptom of COVID-19 with more than 66% of European and US patients reporting some degree of loss of smell. Persistent olfactory dysfunction appears to be commonplace and will drive the demand for general practitioner, otolaryngology or neurology consultation in the next few months - evidence regarding recovery will be essential in counselling our patients.Methods: This was a prospective survey-based data collection and telemedicine follow-up.Results: In total, 751 patients completed the study, of whom 477 were females and 274 males. The mean age of the patients was 41 +/- 13 years (range 18-60). There were 621 patients (83%) who subjectively reported a total loss of smell and 130 (17%) a partial loss. After a mean follow-up of 47 +/- 7 days (range 30-71) from the first consultation, 277 (37%) patients still reported a persistent subjective loss of smell, 107 (14%) reported partial recovery and 367 (49%) reported complete recovery. The mean duration of the olfactory dysfunction was 10 +/- 6 days (range 3-31) in those patients who completely recovered and 12 +/- 8 days (range 7-35) in those patients who partially recovered.Conclusions: According to our results, at this relatively early point in the pandemic, subjective patterns of recovery of olfactory dysfunction in COVID-19 patients are valuable for our patients, for hypothesis generation and for treatment development.