Mixing rapid-acting insulin analogues with insulin glargine in children with type 1 diabetes mellitus
Mixing rapid-acting insulin analogues with insulin glargine in children with type 1 diabetes mellitus
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DOI：
10.1016/j.jpeds.2005.11.036
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发表时间：
2006-04-01
影响因子：
5.1
通讯作者：
Chase, H. Peter
中科院分区：
文献类型：
--
作者：
Fiallo-Scharer, Rosanna;Horner, Brian;Chase, H. Peter
Objective To determine whether mixing insulin glargine (IG) with a rapid-acting insulin (RAI) analogue in the same syringe had any deleterious effects on glycemic control in children with type 1 diabetes mellitus.Study design Data from 55 children mixing the IG with a RAI analogue was collected for 6 months before and 6 months after the insulin mixing began. Data from a control group of 55 children not mixing the insulins was collected at similar intervals. Parameters evaluated included hemoglobin Ale (HbA1c) values, number of non-severe and severe hypoglycemic events, number of diabetic ketoacidosis (DKA) events, and blood glucose distribution patterns.Results After 6 months of study. HbA1c values were equivalent for the control and test groups (5.54 +/- 1.14 vs 3.61 +/- 1.14, respectively; P = 1.0000). Percentages of blood glucose values in, above, and below the target range did not vary significantly in the groups. There were no significant differences in the groups in the occurrence of non-severe or severe hypoglycenuc events or of DKA events.Conclusion There were no significant differences in glycemic control between children who mixed IG in the same syringe with a RAI analogue compared with children who tool: separate injections.
