Intakes of Vitamin B-12 from Dairy Food, Meat, and Fish and Shellfish Are Independently and Positively Associated with Vitamin B-12 Biomarker Status in Pregnant Dutch Women
Intakes of Vitamin B-12 from Dairy Food, Meat, and Fish and Shellfish Are Independently and Positively Associated with Vitamin B-12 Biomarker Status in Pregnant Dutch Women
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DOI：
10.1093/jn/nxy233
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发表时间：
2019-01-01
影响因子：
4.2
通讯作者：
Dagnelie, Pieter C.
中科院分区：
文献类型：
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作者：
Denissen, Karlijn F. M.;Heil, Sandra G.;Dagnelie, Pieter C.
背景：来自不同动物性食物的维生素B-12对孕妇维生素B-12生物标志物状态的影响此前尚未得到评估。目的：我们研究了1266名参加KOALA出生队列研究的孕妇从乳制品、肉类、鱼类（包括贝类）和鸡蛋中摄入的维生素B-12与维生素B-12生物标志物的循环浓度以及维生素B-12缺乏症的关系。方法：在妊娠34-36周采集血样，采用半定量食物频率问卷（FFQ）评估从食物和补充剂中摄取维生素B-12的情况。测定血浆中总维生素B-12、全转钴胺素（holoTC）和甲基丙二酸（MMA）。维生素B-12缺乏症定义为holoTC < 35 pmol/L, MMA > 0.45 mu mol/L。通过线性和逻辑回归分析评估相关性，调整潜在混杂因素。结果：乳制品、肉类和鱼类中维生素B-12的摄入量与血浆维生素B-12、holoTC和MMA之间存在显著的量效关系[p -趋势]，MMA = 0.002；乳制品、肉类和鱼类的p趋势，所有其他标记< 0.001]。三分之一奶牛与一分之一奶牛相比缺乏维生素B-12的OR （95% CI）分别为0.13（0.04,0.49）和0.33（0.11,0.97）和0.25（0.08,0.82）。鸡蛋来源的维生素b12只与holoTC有关。其他分析表明，自定义素食者和ffq定义的乳蛋素食者的膳食维生素B-12总摄入量中位数较低，维生素B-12生物标志物状况也比杂食者和鱼素者差得多。结论：在荷兰孕妇中，从乳制品、肉类和鱼类中摄入更多的维生素B-12与维生素B-12的状态呈正相关，这表明乳制品、肉类和鱼类是怀孕期间生物活性维生素B-12的良好来源。然而，对于（乳）素食者，建议补充维生素B-12。
Background: The effect of vitamin B-12 from different animal foods on vitamin B-12 biomarker status has not previously been evaluated in pregnant women.Objective: We examined the association of vitamin B-12 intake from dairy, meat, fish (including shellfish), and eggs with circulating concentrations of vitamin B-12 biomarkers and with the presence of vitamin B-12 deficiency in 1266 pregnant women participating in the KOALA Birth Cohort Study.Methods: Blood samples were collected in weeks 34-36 of pregnancy, and vitamin B-12 intake from foods and supplements was estimated with a semiquantitative food-frequency questionnaire (FFQ). Total vitamin B-12, holotranscobalamin (holoTC), and methylmalonic acid (MMA) were determined in plasma. Vitamin B-12 deficiency was defined as holoTC < 35 pmol/L and MMA > 0.45 mu mol/L. Associations were evaluated with linear and logistic regression analyses, adjusting for potential confounders.Results: Significant dose-response relations were observed between vitamin B-12 intake from dairy, meat, and fish and plasma vitamin B-12, holoTC, and MMA [P-trend for (shell) fish with MMA = 0.002; P-trend for dairy, meat, and fish with all other markers < 0.001]. The OR (95% CI) of vitamin B-12 deficiency in the third compared with the first tertile of dairy-derived vitamin B-12 was 0.13 (0.04, 0.49), and the ORs for vitamin B-12 from meat and fish were 0.33 (0.11, 0.97) and 0.25 (0.08, 0.82), respectively. Egg-derived vitamin B-12 was only associated with holoTC. Additional analyses showed that self-defined vegetarians and FFQ-defined lacto-ovo-vegetarians had lower median total dietary vitamin B-12 intake and considerably worse vitamin B-12 biomarker status than omnivores and pescatarians.Conclusions: In pregnant Dutch women, higher intakes of vitamin B-12 from dairy, meat, and fish were positively associated with vitamin B-12 status, suggesting that dairy, meat, and fish are good sources of bioactive vitamin B-12 in pregnancy. Nevertheless, for (lacto-) vegetarians, vitamin B-12 supplementation is recommended.