PAROXETINE IN THE TREATMENT OF PANIC DISORDER - A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED STUDY
PAROXETINE IN THE TREATMENT OF PANIC DISORDER - A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED STUDY
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DOI：
10.1192/bjp.167.3.374
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发表时间：
1995-09-01
影响因子：
10.5
通讯作者：
MANNICHE, PM
中科院分区：
文献类型：
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作者：
OEHRBERG, S;CHRISTIANSEN, PE;MANNICHE, PM
背景。本研究比较了帕罗西汀与安慰剂治疗惊恐障碍的疗效和耐受性。接受三周安慰剂治疗后，患者接受帕罗西汀（20、40 或 60 毫克）或安慰剂治疗 12 周，最后接受两周安慰剂治疗。根据疗效和耐受性调整剂量。所有患者均接受标准化认知治疗。结果的主要衡量标准是惊恐发作次数的减少。结果。结果分析显示，两个治疗组在三个主要结果指标中的两个方面存在统计学上显着的差异，即在研究期间惊恐发作总数减少了 50%，并且惊恐发作次数减少到 1 或 0。对于第三个结果衡量标准，即攻击总数相对于基线的平均变化，存在有利于帕罗西汀的积极趋势。主要结局指标的结果得到了次要疗效指标结果的有力支持。此外，帕罗西汀在所有剂量下均具有良好的耐受性。结论。帕罗西汀加认知疗法在治疗惊恐障碍方面比安慰剂加认知疗法显着更有效。
Background. This study compared the efficacy and tolerability of paroxetine with placebo in the treatment of panic disorder.Method. After three weeks of placebo, patients received 12 weeks of treatment with paroxetine (20, 40, or 60 mg) or placebo, and finally two weeks of placebo. Dosages were adjusted according to efficacy and tolerability. Standardised cognitive therapy was given to all patients. The primary measure of outcome was reduction in the number of panic attacks.Results. Analysis of the results showed statistically significant differences in favour of paroxetine between the two treatment groups in two out of the three primary measures of outcome, i.e. 50% reduction in total number of panic attacks and number of panic attacks reduced to one or zero over the study period. For the third measure of outcome, the mean change in the total number of attacks from baseline, there was a positive trend in favour of paroxetine. The results of the primary measures of outcome were strongly supported by the results of the secondary efficacy measures of outcome. In addition, paroxetine, at all doses, was very well tolerated.Conclusion. Paroxetine plus cognitive therapy was significantly more effective than placebo plus cognitive therapy in the treatment of panic disorder.