Connexins in health and disease
Connexins in health and disease
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连接蛋白在健康和疾病中的作用
DOI：
10.1111/cen3.12433
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发表时间：
2018
影响因子：
--
通讯作者：
R. Yamasaki
中科院分区：
文献类型：
--
作者：
R. Yamasaki
间隙连接或半通道在我们身体的所有细胞上表达，并且在稳态和疾病状态中具有非常重要的作用。在人类中发现了21种连接蛋白，它们具有相互补偿的独特特征。每个连接蛋白的解剖表达模式也不同;它们中的一些一起表达，而另一些则不表达。基因突变的连接蛋白基因可诱导遗传性疾病，但获得性疾病也可由原发性或继发性连接蛋白功能障碍引起。在中枢神经系统中，神经胶质细胞是主要的连接蛋白表达细胞。它们利用连接蛋白间隙连接来组装神经胶质网络。本文综述了连接蛋白的基本结构和功能，并探讨了连接蛋白之间的关系及其在疾病病理学中的作用。
Gap junctions or hemichannels are expressed on all cells in our body, and have a highly significant role in homeostasis and in disease states. There are 21 connexins found in humans and they have distinct characteristics that compensate for each other. The anatomical expression pattern also differs between each connexin; some of them are expressed together and some are not. Genetically mutated connexin genes induce inheritable diseases, but acquired disorders can also be caused by primary or secondary connexin dysfunctions. In the central nervous system, glial cells are the main connexin‐expressing cells. They utilize connexin gap junctions to assemble glial networks. The present review not only describes the basic structures and functions of connexins, it also examines the relationships between connexins and their role in disease pathology.
影响因子：
9.8
作者：
Paznekas, WA;Boyadjiev, SA;Jabs, EW
通讯作者：
Jabs, EW