Measurement of lung water content and pleural pressure gradient with magnetic resonance imaging
Measurement of lung water content and pleural pressure gradient with magnetic resonance imaging
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DOI：
10.1097/00005382-199501010-00007
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发表时间：
1995-12-01
影响因子：
3.3
通讯作者：
Paré, PD
中科院分区：
文献类型：
--
作者：
Mayo, JR;MacKay, AL;Paré, PD
本研究的目的是开发一种磁共振（MR）序列能够测量水含量和重力依赖性梯度在正常肺密度。首先，使用2.1T核磁共振（NMR）光谱仪表征来自切除的正常猪肺的MR信号。然后在0.15 T Picker MR扫描仪上建立多回波序列。通过与重量分析肺含水量的比较，在切除的正常猪肺中验证了该序列。最后，该序列被用于五名正常志愿者在安静呼吸期间的俯卧位和仰卧位以及在仰卧位的总肺容量（TLC）。通过MR和重量分析技术测量的肺水比率为0.95 +/- 0.03。俯卧位（0.21 +/- 0.03 g/ml）和仰卧位（0.20 +/- 0.03 g/ml）的平均肺密度无显著差异。TLC时肺密度降低（0.12 +/- 0.01 μ g/ml）（p < 0.01）。在功能残气量（FRC）的所有俯卧位和仰卧位扫描中，肺密度梯度均可见，TLC的梯度平均降低90%。俯卧位的平均估计胸膜压梯度为0.13 ± 0.08 cm H2O/cm肺，仰卧位为0.38 ± 0.23 cm H2O/cm肺。MRI可以测量肺含水量和胸膜压力梯度。
The aim of this study was to develop a magnetic resonance (MR) sequence capable of measuring water content and the gravity-dependent gradient in lung density in normal lung. First, the MR signal from excised normal pig lung was characterized using a 2.1 T nuclear magnetic resonance (NMR) spectrometer. A multiecho, sequence was then developed on a 0.15 T Picker MR scanner. This sequence was validated in excised normal pig lung by comparison with gravimetric lung water content. Finally, this sequence was used in five normal volunteers in the prone and supine positions during quiet breathing and in the supine position at total lung capacity (TLC). The ratio of lung water measured by MR and gravimetric techniques was 0.95 +/- 0.03. There was no significant difference in average lung density in the prone (0.21 +/- 0.03 g/ml) and in the supine (0.20 +/- 0.03 g/ml) positions. Lung density decreased at TLC (0.12 +/- 0.01 g/ml) (p < 0.01). Gradients in lung density were visible in all prone and supine scans at functional residual capacity (FRC), and on average the gradients were decreased by 90% at TLC. The average estimated pleural pressure gradient in the prone position was 0.13 0.08 cm H2O/cm lung and in the supine position was 0.38 +/- 0.23 cm H2O/cm lung. MRI allows measurement of lung water content and pleural pressure gradient.